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Sox10 (E6B6I) CO-0080-647 SignalStar Oligo-Antibody Pair
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Sox10 (E6B6I) CO-0080-647 SignalStar Oligo-Antibody Pair

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产品介绍
产品介绍
产品信息
来源纯化

Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Gly446 of human Sox10 protein.

简单描述

SignalStar multiplex immunohistochemistry (IHC) is an advanced technology for labeling multiple proteins simultaneously in tissue samples using specific primary antibodies and fluorescent detection reagents. This technology offers accuracy and reliability in visualizing and analyzing protein expression while maintaining spatial context and tissue architecture.

SignalStar Oligo-Antibody Pairs are compatible with the SignalStar Multiplex IHC Buffer Kits for use in fluorescent multiplex imaging experiments. This product includes the oligo-conjugated antibodies and complementary oligos required for labeling your target protein on up to 10 slides. SignalStar Multiplex IHC Buffer Kits are required to amplify and image the target signal. Multiple oligo-antibody pairs can be conveniently combined into a multiplex panel using the SignalStar Multiplex IHC Panel Builder. SignalStar Multiplex IHC Kits & Reagents are not compatible with all of Cell Signaling Technology® products and protocols that are recommended for use in immunohistochemical assays.

商品描述

Product Usage Information

ApplicationDilution
SignalStar™ Leica Bond1:50 - 1:200
SignalStar™ Manual1:50 - 1:200
应用
目标/特异性

Specificity/Sensitivity

Sox10 (E6B6I) XP Rabbit mAb (SignalStar™ Conjugate 0080) recognizes endogenous levels of total Sox10 protein. This antibody also recognizes presumptive sumoylated forms of Sox10 protein.

Species Reactivity:

Human

背景
背景
SRY-box 10 (Sox10) is a member of the SOX (SRY-related HMG-box) family of transcription factors involved in the regulation of embryonic development and the determination of cell fate. Sox10 is an important regulator of neural crest and peripheral nervous system development (1-3). Mutations in the SOX10 gene are associated with a group of auditory-pigmentary developmental disorders, including Waardenburg and Waardenburg-Shah syndromes (3,4). Research studies suggest an oncogenic role for Sox10 in various tumor types, such as hepatocellular carcinoma and melanoma (5,6). 1.Hong, C.S. and Saint-Jeannet, J.P. (2005) Semin Cell Dev Biol 16, 694-703. 2.Britsch, S. et al. (2001) Genes Dev 15, 66-78. 3.Bondurand, N. and Sham, M.H. (2013) Dev Biol 382, 330-43. 4.Mollaaghababa, R. and Pavan, W.J. (2003) Oncogene 22, 3024-34. 5.Zhou, D. et al. (2014) Tumour Biol 35, 9935-40. 6.Graf, S.A. et al. (2014) J Invest Dermatol 134, 2212-20.
制备和贮存
保存方式

SignalStar conjugates are supplied in PBS (pH 7.2), less than 0.1% sodium azide, 2 mM EDTA, 0.05% Triton X-100, 2 mg/mL BSA, and 50% glycerol. Complementary oligos are supplied in nuclease-free water. Store at -20°C. Do not aliquot the antibody. All components in this kit are stable for at least 12 months when stored at the recommended temperature.

数据库链接
Entrez-Gene ID
6663
UniProt ID
P56693
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货号:
49478S
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