Spermine synthase (F9W1S) Rabbit mAb

Polyamines, including spermine, spermidine, and putrescine, are involved in many cellular processes, for example, cell proliferation, differentiation, apoptosis, the synthesis of proteins and nucleic acids, the regulation of ion channel activity, and the protection from oxidative injury (1). The cellular content of polyamines is tightly regulated; their biosynthesis is catalyzed by different enzymes, including spermine synthase (SMS) and spermidine synthase (SRM). The enzymes N1-acetylpolyamine oxidase (PAOX), spermidine/spermine N1-acetyltransferase (SAT1), and spermine oxidase (SMOX) are involved in the polyamine catabolism (1). SMS catalyzes spermine production from spermidine and decarboxylated S-adenosylmethionine (2). Mutations in SMS cause Snyder-Robinson Syndrome, characterized by developmental delay, muscle/bone abnormalities, and intellectual disability (3-6). A recent study has indicated the potential role of polyamines in autophagy and tauopathy, where a reduction in SMS had a protective effect against tauopathy in a Drosophila model and human cells (7). 1.Cervelli, M. et al. (2022) Biomedicines 10, 1756. doi: 10.3390/biomedicines10071756. 2.Wu, H. et al. (2008) J Biol Chem 283, 16135-46. 3.de Alencastro, G. et al. (2008) J Med Genet 45, 539-43. 4.Zhang, Z. et al. (2013) Hum Mol Genet 22, 3789-97. 5.Peron, A. et al. (2013) Am J Med Genet A 161A, 2316-20. 6.Li, C. et al. (2017) Nat Commun 8, 1257. 7.Tao, X. et al. (2024) Cell Death Dis 15, 333.