PCM-1 (E4I1Q) Rabbit mAb

The centrosome is composed of a pair of centrioles surrounded by electron-dense pericentriolar material and functions as the microtubule-organizing center responsible for microtubule nucleation and spindle organization during cell cycle progression (1). Pericentriolar material 1 (PCM-1) is a large, 228 kDa protein associated with the centrosome in a cell cycle-dependent manner (2). PCM-1 localizes to small cytoplasmic granules called centriolar satellites (3). PCM-1 is required for the assembly of several centrosomal proteins, including centrin, pericentrin, ninein, NEK2, and CEP250 (4-8). Chromosomal translocations involving genes encoding PCM-1 and the tyrosine kinases Ret and Jak2 are associated with some cancers, including papillary thyroid carcinoma and myeloid leukemia (9-11). 1.Zimmerman, W. and Doxsey, S.J. (2000) Traffic 1, 927-34. 2.Balczon, R. et al. (1994) J Cell Biol 124, 783-93. 3.Kubo, A. and Tsukita, S. (2003) J Cell Sci 116, 919-28. 4.Kim, J. et al. (2008) Hum Mol Genet 17, 3796-805. 5.Dammermann, A. and Merdes, A. (2002) J Cell Biol 159, 255-66. 6.Li, Q. et al. (2001) J Cell Sci 114, 797-809. 7.Hames, R.S. et al. (2005) Mol Biol Cell 16, 1711-24. 8.Mack, G.J. et al. (1998) Arthritis Rheum 41, 551-8. 9.Corvi, R. et al. (2000) Oncogene 19, 4236-42. 10.Reiter, A. et al. (2005) Cancer Res 65, 2662-7. 11.Bousquet, M. et al. (2005) Oncogene 24, 7248-52.