T-bet/TBX21 (D6N8B) R mAb (InTraSeq 3‘ Conjugate 3009)

The T-box gene family consists of transcription factors characterized by a related DNA-binding domain (T-box) of approximately 200 amino acids (1,2). The T-box genes exhibit diverse temporal and spatial patterns in the developing embryo. Studies have demonstrated members of this family play crucial roles during embryogenesis in a wide range of organisms by regulating cell fate decisions to establish the early body plan and to regulate later processes underlying organogenesis (3-5). Mutations in T-box genes are associated with many developmental defects (6). Recent studies also indicate potential roles in cancer by members of the T-box family (7-9).T-bet, also as known as TBX21, plays a critical role in development and maintenance of type 1 helper T (Th1) and T-bet deficient mice display impaired Th1 differentiation (10,11). 1.Wilkinson, D.G. et al. (1990) Nature 343, 657-9. 2.Papaioannou, V.E. and Silver, L.M. (1998) Bioessays 20, 9-19. 3.Showell, C. et al. (2004) Dev Dyn 229, 201-18. 4.Papaioannou, V.E. (2001) Int Rev Cytol 207, 1-70. 5.Hoogaars, W.M. et al. (2007) Cell Mol Life Sci 64, 646-60. 6.Baldini, A. (2004) Curr Opin Cardiol 19, 201-4. 7.Abrahams, A. et al. (2010) IUBMB Life 62, 92-102. 8.Rowley, M. et al. (2004) J Mammary Gland Biol Neoplasia 9, 109-18. 9.Yang, X.R. et al. (2009) Nat Genet 41, 1176-8. 10.Ho, I.C. and Glimcher, L.H. (2002) Cell 109 Suppl, S109-20. 11.Peng, S.L. (2006) Cell Mol Immunol 3, 87-95.