beta-Synuclein (F8O8P) Rabbit mAb

The synuclein family, consisting of α-synuclein, β-synuclein, and γ-synuclein, is a group of small, soluble proteins containing a highly conserved α-helical lipid-binding motif. α-synuclein and β-synuclein are primarily expressed in brain tissue, where they colocalize within presynaptic terminals (1,2). α-synuclein is linked genetically and neuropathologically to Parkinson’s disease and other neurodegenerative diseases, called synucleinopathies, characterized by the presence of intracellular α-synuclein aggregates, the main component of Lewy bodies (3,4). β-synuclein has been shown to inhibit α-synuclein aggregation and ameliorate α-synuclein neurotoxicity (5-7). Studies have shown that β-synuclein levels are elevated in early and advanced Alzheimer’s disease, Creutzfeldt-Jakob disease, and traumatic brain injury, showing strong potential for use as a synaptic damage biomarker (8-9). 1.George, J.M. (2002) Genome Biol 3, REVIEWS3002. 2.Vigneswara, V. et al. (2013) PLoS One 8, e61442. 3.Kim, W.S. et al. (2014) Alzheimers Res Ther 6, 73. 4.Stefanis, L. (2012) Cold Spring Harb Perspect Med 2, a009399. 5.Hashimoto, M. et al. (2001) Neuron 32, 213-23. 6.Brown, J.W. et al. (2016) Sci Rep 6, 36010. 7.Fan, Y. et al. (2006) Hum Mol Genet 15, 3002-11. 8.Halbgebauer, S. et al. (2021) J Neurol Neurosurg Psychiatry 92, 349-356. 9.Halbgebauer, R. et al. (2022) Int J Mol Sci 23, 9639. doi: 10.3390/ijms23179639.