RTN3 (F5X9D) Rabbit mAb

Reticulon-3 (RTN3), a member of the reticulon protein family, plays a crucial role in maintaining the tubular shape and structural integrity of the endoplasmic reticulum (ER) network (1,2). The longest isoform of RTN3 (Rtn3L) carries six active LC3-interacting region domains, which are essential for LC3/GABARAP binding, fragmentation of ER tubules, and its function as an ER-phagy receptor (3,4). Rtn3L is also recruited to ER-endosome membrane contact sites by the endosomal protein Rab9a, where it promotes endosome maturation and cargo sorting (5). RTN3 is highly expressed in neuronal tissues and is a negative modulator of β-amyloid converting enzyme 1 (BACE1), the enzyme that cleaves amyloid precursor protein (APP) to release β-amyloid peptides (6). Therefore, altered expression of RTN3 may modulate amyloid plaque formation, a hallmark of Alzheimer's disease (7,8). 1.Voeltz, G.K. et al. (2006) Cell 124, 573-86. 2.Chen, Y.J. et al. (2020) J Cell Biol 219, e201908182. doi: 10.1083/jcb.201908182. 3.Grumati, P. et al. (2017) Elife 6, doi: 10.7554/eLife.25555. 4.Yang, M. et al. (2021) Front Cell Dev Biol 9, 684526. 5.Wu, H. and Voeltz, G.K. (2021) Dev Cell 56, 52-66.e7. 6.He, W. et al. (2004) Nat Med 10, 959-65. 7.Shi, Q. et al. (2009) J Neurosci 29, 9163-73. 8.Sharoar, M.G. and Yan, R. (2017) Rev Neurosci 28, 145-154.