NMDAR2A (GLUN2A) (EXTRACELLULA

品牌： Thermo

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产品介绍

产品信息

应用

建议稀释比

已发表文章

免疫组化（冰冻） (IHC (F))

1:80

产品规格

种属反应

Human,Mouse,Rat

宿主/亚型

Rabbit / IgG

分类

Polyclonal

类型

Antibody

抗原

GHSHDVTERELRN(C), corresponding to amino acid residues 41-53 of rat NR2A, Extracellular, N-terminus

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偶联物

Atto™ 488 Atto™ 488 Atto™ 488

激发/发射光谱

501/523 nm

形式

Lyophilized

浓度

1 mg/mL

纯化类型

Antigen affinity chromatography

保存液

PBS, pH 7.4, with 1% BSA

内含物

0.05% sodium azide

保存条件

-20° C, Avoid Freeze/Thaw Cycles

运输条件

Ambient (domestic); Wet ice (international)

产品详细信息

Reconstitution: 50 µL double distilled water (DDW), depending on the sample size. The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20C. The reconstituted solution can be stored at 4C for up to 1 week. For longer periods, small aliquots should be stored at -20C. Avoid multiple freezing and thawing. Centrifuge all antibody preparations before use (10000 x g 5 min).

靶标信息

N-methyl-D-aspartate (NMDA) receptors are a class of ionotropic glutamate-gated ion channels. These receptors have been shown to be involved in long-term potentiation, an activity-dependent increase in the efficiency of synaptic transmission thought to underlie certain kinds of memory and learning. NMDA receptor channels are heteromers composed of the key receptor subunit NMDAR1 (GRIN1) and 1 or more of the 4 NMDAR2 subunits: NMDAR2A (GRIN2A), NMDAR2B (GRIN2B), NMDAR2C (GRIN2C) and NMDAR2D (GRIN2D). Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

生物信息学

蛋白别名: GluN2A; GluRepsilon1; Glutamate [NMDA] receptor subunit epsilon-1; glutamate receptor; Glutamate receptor ionotropic, NMDA 2A; glutamate receptor, ionotropic, N-methyl D-aspartate 2A; hNR2A; N-methyl D-aspartate receptor subtype 2A; N-methyl-D-aspartate receptor channel, subunit epsilon-1; N-methyl-D-aspartate receptor subunit 2A; NMDA Receptor 2A; NMDAR 2A; NMDAR2A; OTTHUMP00000160135; OTTHUMP00000174531

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基因别名: EPND; FESD; GluN2A; GRIN2A; LKS; NMDAR2A; NR2A

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UniProt ID:(Human) Q12879, (Mouse) P35436, (Rat) Q63728

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Entrez Gene ID:(Human) 2903, (Mouse) 14811, (Rat) 24409

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参与通路

MAPK cascade startle response response to amphetamine transport glutamate receptor signaling pathway chemical synaptic transmission learning or memory memory protein localization visual learning response to wounding sensory perception of pain neurogenesis sleep directional locomotion ionotropic glutamate receptor signaling pathway negative regulation of protein catabolic process dopamine metabolic process serotonin metabolic process response to drug positive regulation of apoptotic process positive regulation of GTPase activity response to ethanol regulation of sensory perception of pain excitatory postsynaptic potential long-term synaptic potentiation calcium ion transmembrane transport positive regulation of long-term synaptic potentiation action potential ion transport cation transport calcium ion transport learning locomotory behavior positive regulation of cell death ion transmembrane transport regulation of ion transmembrane transport synaptic transmission, glutamatergic locomotion regulation of membrane potential regulation of synaptic plasticity regulation of long-term neuronal synaptic plasticity rhythmic process modulation of synaptic transmission detection of mechanical stimulus involved in sensory perception of pain protein tetramerization regulation of postsynaptic membrane potential cellular response to amino acid stimulus cellular response to zinc ion cation transmembrane transport positive regulation of excitatory postsynaptic potential response to light stimulus response to carbohydrate response to manganese ion response to organic cyclic compound response to amine spinal cord development hippocampus development cerebral cortex development response to cocaine response to calcium ion response to methylmercury response to other organism response to ammonium ion response to fungicide cellular response to magnesium ion cellular response to manganese ion cellular response to dsRNA cellular response to growth factor stimulus cellular response to lipid

参考图片

Expression of NR2A in mouse brain sections - Immunohistochemical staining of perfusion-fixed frozen mouse brain sections using Anti-NMDAR2A (GluN2A) (extracellular)-ATTO Fluor-488 Antibody (#AGC-002-AG), (1:80). A. NR2A staining (green) in striatum is detected in neuronal profiles. B. NR2A staining in cingulate cortex is also detected in neuronal profiles. Cell nuclei are labeled with DAPI (blue).

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货号：

AGC-002-AG-50UL-Thermo

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询价

50UL

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