NMDAR2B (GLUN2B) (EXTRACELLULA

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NMDAR2B (GLUN2B) (EXTRACELLULA

品牌： Thermo

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产品介绍

产品信息

应用

建议稀释比

已发表文章

免疫组化（冰冻） (IHC (F))

1:50

产品规格

种属反应

Human,Mouse,Rat

宿主/亚型

Rabbit / IgG

分类

Polyclonal

类型

Antibody

抗原

(C)NTHEKRIYQSNMLNR, corresponding to amino acid residues323-337 of rat NMDAR2B, Extracellular, N-terminus

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偶联物

Atto™ 594 Atto™ 594 Atto™ 594

激发/发射光谱

602/622 nm

形式

Lyophilized

浓度

1 mg/mL

纯化类型

Antigen affinity chromatography

保存液

PBS, pH 7.4, with 1% BSA

内含物

0.05% sodium azide

保存条件

-20° C, Avoid Freeze/Thaw Cycles

运输条件

Ambient (domestic); Wet ice (international)

产品详细信息

Reconstitution: 50 µL double distilled water (DDW), depending on the sample size. The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20C. The reconstituted solution can be stored at 4C for up to 1 week. For longer periods, small aliquots should be stored at -20C. Avoid multiple freezing and thawing. Centrifuge all antibody preparations before use (10000 x g 5 min).

靶标信息

NMDAR2B is a member of the N-methyl-D-aspartate (NMDA) class of ionotropic glutamate receptors. NMDA receptors (NMDAR) have been shown to be involved in long-term potentiation, an activity-dependent increase in the efficiency of synaptic transmission thought to underlie certain kinds of memory and learning. NMDAR play a role in neuronal development and has been implicated in several disorders of the central nervous system including Alzheimer’s Disease, epilepsy and ischemic neuronal cell death. Overexpression of the NR2B subunit of the receptor has been associated with increases in learning and memory while aged, memory impaired animals have deficiencies in NR2B expression. Tyr1472 on NR2B is phosphorylated and this may lead to the increased expression of the NMDAR at the synapse that plays a role in synaptic plasticity. NMDR2B is a heterotrimer comprised of seven enetically encoded and differentially expressed subunits that include NR1, NR2 and NR3. Diseases associated with the dysfunction of NMDAR2B include epileptic encephalopathy, autosomal dominant 6-related mental retardation.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

生物信息学

蛋白别名: GluN2B; GluRepsilon2; Glutamate [NMDA] receptor subunit epsilon-2; glutamate receptor; Glutamate receptor ionotropic, NMDA 2B; glutamate receptor subunit epsilon-2; glutamate receptor, ionotropic, N-methyl D-aspartate 2B; glutamate receptor, ionotropic, NMDA2B; GRIN 2B; HGNC:4586; hNR 3; MGC142178; MGC142180; N-methyl D-aspartate receptor 2B; N-methyl D-aspartate receptor subtype 2B; N-methyl-D-aspartate receptor subunit 3; NMDAR2B; NMDE2; NME2; NR2B; NR3

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基因别名: AW490526; EIEE27; GluN2B; GRIN2B; hNR3; MRD6; NMDAR2B; NR2B

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UniProt ID:(Human) Q13224, (Mouse) Q01097, (Rat) Q00960

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Entrez Gene ID:(Human) 2904, (Mouse) 14812, (Rat) 24410

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参与通路

MAPK cascade transport glutamate receptor signaling pathway chemical synaptic transmission learning or memory ion transmembrane transport ionotropic glutamate receptor signaling pathway positive regulation of GTPase activity response to ethanol ephrin receptor signaling pathway action potential behavioral fear response in utero embryonic development startle response suckling behavior ion transport cation transport calcium ion transport sensory organ development learning memory associative learning embryo development regulation of protein kinase A signaling positive regulation of cell death positive regulation of glutamate secretion synaptic transmission, glutamatergic fear response receptor clustering regulation of MAPK cascade regulation of synaptic plasticity regulation of neuronal synaptic plasticity regulation of long-term neuronal synaptic plasticity behavioral response to pain rhythmic process positive regulation of synaptic transmission detection of mechanical stimulus involved in sensory perception of pain regulation of postsynaptic membrane potential excitatory postsynaptic potential long-term synaptic potentiation calcium ion transmembrane transport cation transmembrane transport response to amphetamine long-term memory response to mechanical stimulus response to toxic substance response to carbohydrate response to manganese ion cellular response to magnesium starvation response to organic cyclic compound response to amine hippocampus development cerebral cortex development response to magnesium ion multicellular organismal response to stress response to cytokine response to cocaine response to calcium ion response to methylmercury response to electrical stimulus response to other organism response to growth hormone response to fungicide cellular response to amino acid stimulus cellular response to manganese ion cellular response to dsRNA cellular response to growth factor stimulus cellular response to lipid cellular response to organic cyclic compound

参考图片

Expression of NMDAR2B (NR2B) in rat DRG - Immunohistochemical staining of rat dorsal root ganglia (DRG) frozen sections using Anti-NMDAR2B (GluN2B) (extracellular)-ATTO Fluor-594 Antibody (#AGC-003-AR), (red), (1:50). Staining is present in neuronal cell bodies. Hoechst 33342 is used as the counterstain (blue).

Multiplex staining of GluN2A and GluN2B in mouse deep cerebellar nucleus - Immunohistochemical staining of perfusion-fixed frozen mouse brain sections using Anti-NMDAR2B (GluN2B) (extracellular)-ATTO Fluor-594 Antibody (#AGC-003-AR), (1:60) and Anti-NMDAR2A (GluN2A) (extracellular) Antibody (#AGC-002), (1:200). A. Sections were incubated with Anti-NMDAR2A (GluN2A) (extracellular) Antibody , followed by goat Anti-rabbit-Alexa-488 (green). B. The same sections were incubated with Anti-NMDAR2B (GluN2B) (extracellular)-ATTO Fluor-594 Antibody (red). C. Merge of A and B demonstrates the ubiquitous colocalization of the GluN2A and GluN2B subunits in cells with neuronal profiles in this nucleus. Arrows point at an example of NR2A and NR2B co-expression.

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货号：

AGC-003-AR-50UL-Thermo

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询价

50UL

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