全部商品分类
NMDAR2B (GLUN2B) (EXTRACELLULA
下载产品说明书
用小程序，查商品更便捷
收藏
对比
咨询种属反应
宿主/亚型
分类
类型
抗原
偶联物
形式
浓度
纯化类型
保存液
内含物
保存条件
运输条件
产品详细信息
Reconstitution: 25 µL, 50 µL or 0.2 mL double distilled water (DDW), depending on the sample size. The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20C. The reconstituted solution can be stored at 4C, protected from the light, for up to 1 week. For longer periods, small aliquots should be stored at -20C. Avoid multiple freezing and thawing. Centrifuge all antibody preparations before use (10000 X g 5 min).
靶标信息
NMDAR2B is a member of the N-methyl-D-aspartate (NMDA) class of ionotropic glutamate receptors. NMDA receptors (NMDAR) have been shown to be involved in long-term potentiation, an activity-dependent increase in the efficiency of synaptic transmission thought to underlie certain kinds of memory and learning. NMDAR play a role in neuronal development and has been implicated in several disorders of the central nervous system including Alzheimer’s Disease, epilepsy and ischemic neuronal cell death. Overexpression of the NR2B subunit of the receptor has been associated with increases in learning and memory while aged, memory impaired animals have deficiencies in NR2B expression. Tyr1472 on NR2B is phosphorylated and this may lead to the increased expression of the NMDAR at the synapse that plays a role in synaptic plasticity. NMDR2B is a heterotrimer comprised of seven enetically encoded and differentially expressed subunits that include NR1, NR2 and NR3. Diseases associated with the dysfunction of NMDAR2B include epileptic encephalopathy, autosomal dominant 6-related mental retardation.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
生物信息学
蛋白别名: GluN2B; GluRepsilon2; Glutamate [NMDA] receptor subunit epsilon-2; glutamate receptor; Glutamate receptor ionotropic, NMDA 2B; glutamate receptor subunit epsilon-2; glutamate receptor, ionotropic, N-methyl D-aspartate 2B; glutamate receptor, ionotropic, NMDA2B; GRIN 2B; HGNC:4586; hNR 3; MGC142178; MGC142180; N-methyl D-aspartate receptor 2B; N-methyl D-aspartate receptor subtype 2B; N-methyl-D-aspartate receptor subunit 3; NMDAR2B; NMDE2; NME2; NR2B; NR3
基因别名: AW490526; EIEE27; GluN2B; GRIN2B; hNR3; MRD6; NMDAR2B; NR2B
UniProt ID:(Human) Q13224, (Mouse) Q01097, (Rat) Q00960
Entrez Gene ID:(Human) 2904, (Mouse) 14812, (Rat) 24410
参考图片
Expression of NMDA receptor 2B in rat hippocampus - Immunohistochemical staining of rat hippocampal CA1 frozen sections stained with Anti-NMDAR2B (GluN2B) (extracellular) Antibody (#AGC-003), (1:100). A. NMDAR2B (green) appears in the pyramidal layer of CA1. B. Staining of neurofilament 200 (red) identifies neuronal processes. C. Confocal merge demonstrates localization of NMDAR2B in cells andnot in processes.
Expression of NMDA receptor 2B in rat cortex - Immunohistochemical stainingof rat parietal cortex frozen sections stained with Anti-NMDAR2B (GluN2B) (extracellular) Antibody (#AGC-003), (1:100). A. NMDAR2B (green) appears in the pyramidal layer of layer 5. B. Staining of neurofilament 200 (red) identifies neuronal processes. C. Confocal merge demonstrates localization of NMDAR2B in cells.
Western blot analysisof rat brain lysates: - 1. Anti-NMDAR2B (GluN2B) (extracellular) Antibody (#AGC-003), (1:600). 2. Anti-NMDAR2B (GluN2B) (extracellular) Antibody , preincubated with NMDAR2B/GluN2B (extracellular) Blocking Peptide (#BLP-GC003).
Immunoprecipitation of rat brain lysates: - 1. Cell lysates. 2. Cell lysates + protein A beads + Anti-NMDAR2B (GluN2B) (extracellular) Antibody (#AGC-003).3. Cell lysates + protein A beads + pre-immune rabbit serum.Red arrow indicates the NMDA receptor 2B protein while the black arrow shows the IgG heavy chain. Immunoblot was performed with Anti-NMDAR2B (GluN2B) (extracellular) Antibody .