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产品详细信息
Reconstitution: 25 µL, 50 µL or 0.2 mL double distilled water (DDW), depending on the sample size. The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20C. The reconstituted solution can be stored at 4C, protected from the light, for up to 1 week. For longer periods, small aliquots should be stored at -20C. Avoid multiple freezing and thawing. Centrifuge all antibody preparations before use (10000 X g 5 min).
靶标信息
TRPV1 (Transient Receptor Potential Cation Channel Subfamily V Member 1) is a receptor for capsaicin, the main pungent ingredient in hot chili peppers, and elicits a sensation of burning pain by selectively activating sensory neurons. TRPV1 is a non-selective cation channel that is structurally related to members of the TRP family of ion channels such as TRPC3 and TRPC6. TRPV1 is permeable to calcium, magnesium, and monovalent cations of sodium and potassium. Structurally, TRPV1 contains 6 trans-membrane domains, a P-loop membrane domain and 3 ankyrin repeat domains. TRPV1 is also activated by increases in temperature in the noxious range, suggesting that it functions as a transducer of painful thermal stimuli in vivo. TRPV1 seems to mediate proton influx and may be involved in intracellular acidosis in nociceptive neurons. The expression of TRPV1 appears to be limited to neurons within the sensory ganglia. Four transcript variants encoding TRPV1 with variations in th 5' UTR sequence have been described. Diseases associated with TRPV1 include Irritable Bowel Syndrome (IBS) and Bladder Disease.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
生物信息学
蛋白别名: Capsaicin receptor; cation channel; DKFZp434K0220; Osm-9-like TRP channel 1; OTRPC1; Transient receptor potential cation channel subfamily V member 1; transient receptor potential cation channel V1; transient receptor potential cation channel, subfamily V, member 1; transient receptor potential vanilloid 1 supraoptic nucleus; transient receptor potential vanilloid 1a; transient receptor potential vanilloid 1b; TrpV1; Vanilloid receptor; Vanilloid receptor 1; vanilloid receptor subtype 1; vanilloid receptor type 1 like protein 1; Vanilloid receptor type 1-like; vanilloid type 1 receptor
基因别名: OTRPC1; TRPV1; TRPV1_SON; TRPV1alpha; TRPV1beta; VR-1; VR.5'sv; VR1; Vr1l; Vr1l1
UniProt ID:(Human) Q8NER1, (Rat) O35433, (Mouse) Q704Y3
Entrez Gene ID:(Human) 7442, (Rat) 83810, (Mouse) 193034
参考图片
Expression of TRPV1 in rat DRG primary culture - Immunocytochemical staining of paraformaldehyde-fixed and permeabilized rat dorsal root ganglia (DRG) primary cells with Anti-TRPV1 (VR1) Antibody (#ACC-030), (1:200).A. Staining followed by goat Anti-rabbit-AlexaFluor-555 secondary Antibody . B. Nuclear staining using the cell-permeable dye Hoechst 33342. C. Merged image of panels A and B.
Expression of TRPV1 in rat DRG - Immunohistochemical staining ofratdorsal root ganglion (DRG) using Anti-TRPV1 (VR1) Antibody (#ACC-030). A. TRPV1 (red) in DRG neurons. B. Staining with mouse Anti-Parvalbumin (green) in the same DRG section. C. Confocal merge of TRPV1 and Parvalbumin demonstratescolocalization (arrows).
Western blot analysisof human TRPV1 transfected HEK-293 cells: - 1. Anti-TRPV1 (VR1) Antibody (#ACC-030), (1:200). 2. Anti-TRPV1 (VR1) Antibody , preincubated with TRPV1/VR1 Blocking Peptide (#BLP-CC030).
Western blot analysis of rat DRG lysate: - 1. Anti-TRPV1 (VR1) Antibody (#ACC-030), (1:200). 2. Anti-TRPV1 (VR1) Antibody , preincubated with TRPV1/VR1 Blocking Peptide (#BLP-CC030).