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产品详细信息
Reconstitution: 25 µL, 50 µL or 0.2 mL double distilled water (DDW), depending on the sample size. The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20C. The reconstituted solution can be stored at 4C for up to 1 week. For longer periods, small aliquots should be stored at -20C. Avoid multiple freezing and thawing. Centrifuge all antibody preparations before use (10000 x g 5 min).
靶标信息
After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
生物信息学
蛋白别名: acetylcholine receptor; acetylcholine receptor alpha 6 neural; alpha6 nAChR; cholinergic receptor; cholinergic receptor, nicotinic, alpha polypeptide 6; Neuronal acetylcholine receptor subunit alpha-6; nicotinic acetylcholine receptor subunit alpha 6
基因别名: Acra6; Chrna6; Nica6
UniProt ID:(Rat) P43143, (Mouse) Q9R0W9
Entrez Gene ID:(Rat) 81721, (Mouse) 11440
参考图片
Expression of nAChR alpha 6 in rat PC12 cells - Cell surface detection of nAChR alpha 6 in live intact rat PC12 pheochromocytoma cells. A. Extracellular staining of cells with Anti-Nicotinic Acetylcholine Receptor alpha 6 (CHRNA6) (extracellular) Antibody (#ANC-006), (1:50), followed by goat Anti-rabbit-Alexa Fluor- 594secondary Antibody (red). B. Live image of the cells. C. Merge of the two images.
Expression ofnAChR alpha 6in rat striatum - Immunohistochemical staining of immersion-fixed, free floating rat brain frozen sections using Anti-Nicotinic Acetylcholine Receptor alpha 6 (CHRNA6) (extracellular) Antibody (#ANC-006), (1:100). A. nAChR alpha 6 staining (red)is detectedin the striatal matrix (M) but not in the striatal patches (arrows) nor in the overlying corpus callosum (CC). B. DAPI (blue) counterstain reveals the outline of the striatal matrix and patches and the overlying corpus callosum.
Western blot analysis of mouse (lanes 1 and 3) and rat (lanes 2 and 4) brain lysates: - 1,2. Anti-Nicotinic Acetylcholine Receptor alpha 6 (CHRNA6) (extracellular) Antibody (#ANC-006), (1:1000).3,4. Anti-Nicotinic Acetylcholine Receptor alpha 6 (CHRNA6) (extracellular) Antibody , preincubated with Nicotinic Acetylcholine Receptor alpha 6/CHRNA6 (extracellular) Blocking Peptide (#BLP-NC006).