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产品详细信息
Reconstitution: 50 µL or 0.2 mL double distilled water (DDW), depending on the sample size. The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20C. The reconstituted solution can be stored at 4C for up to 1 week. For longer periods, small aliquots should be stored at -20C. Avoid multiple freezing and thawing. Centrifuge all antibody preparations before use (10000 x g 5 min).
靶标信息
After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
生物信息学
蛋白别名: acetylcholine receptor; Acetylcholine receptor beta 4; acetylcholine receptor, nicotinic, beta 4 (neuronal); cholinergic receptor; cholinergic receptor, nicotinic beta 4; cholinergic receptor, nicotinic, beta 4 (neuronal); cholinergic receptor, nicotinic, beta polypeptide 4; N-alpha 2; nAChRB4; Neuronal acetylcholine receptor non-alpha-2 chain; Neuronal acetylcholine receptor subunit beta-4; neuronal nicotinic receptor beta 4 subunit; nicotinic acetylcholine receptor beta4 subunit
基因别名: Acrb-4; Acrb4; CHRNB4
UniProt ID:(Human) P30926, (Mouse) Q8R493, (Rat) P12392
Entrez Gene ID:(Human) 1143, (Mouse) 108015, (Rat) 25103
参考图片
Expression of nAChR beta 4 in rat PC12 cells - Cell surface detection of nAChR beta 4 in live intact rat pheochromocytoma PC12 cells. A. Cells were stained with Anti-Nicotinic Acetylcholine Receptor beta 4 (CHRNB4) (extracellular) Antibody (#ANC-014), (1:100), followed by goat Anti-rabbit-AlexaFluor-594 secondary Antibody (red). B. Cell nuclei were visualized using Hoechst 33342 (blue). C. Merge of the two images.
Expression of nAChR beta 4in rat dorsal root ganglion - Immunohistochemical staining of rat dorsal root ganglion (DRG) frozen sections using Anti-Nicotinic Acetylcholine Receptor beta 4 (CHRNB4) (extracellular) Antibody (#ANC-014). A. nAChR beta 4 labeling (red) appears in neuronal cell bodies. B. Nuclear staining using DAPI as counterstain (blue). C. Merged images of A and B.
Western blot analysis of SH-SY5Y human neuroblastoma cell lysate (lanes 1 and 4), rat dorsal root ganglion (lanes 2 and 5) and mouse brain (lanes 3 and 6) lysates: - 1-3. Anti-Nicotinic Acetylcholine Receptor beta 4 (CHRNB4) (extracellular) Antibody (#ANC-014), (1:200).4-6. Anti-Nicotinic Acetylcholine Receptor beta 4 (CHRNB4) (extracellular) Antibody , preincubated with Nicotinic Acetylcholine Receptor beta 4/CHRNB4 (extracellular) Blocking Peptide (#BLP-NC014).