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产品详细信息
Reconstitution: 25 µL, 50 µL or 0.2 mL double distilled water (DDW), depending on the sample size. The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20C. The reconstituted solution can be stored at 4C for up to 1 week. For longer periods, small aliquots should be stored at -20C. Avoid multiple freezing and thawing. Centrifuge all antibody preparations before use (10000 x g 5 min).
靶标信息
Tpcn2 is a nicotinic acid adenine dinucleotide phosphate (NAADP) receptor that may function as one of the major voltage-gated Ca(2+) channels (VDCC) across the lysosomal membrane. Tpcn2 may also be involved in smooth muscle contraction. The Tpcn2 gene encodes a putative cation-selective ion channel with two repeats of a six-transmembrane-domain. The Tpcn2 protein localizes to lysosomal membranes and enables nicotinic acid adenine dinucleotide phosphate (NAADP) -induced calcium ion release from lysosome-related stores. Tpcn2 is a ubiquitously expressed gene that has elevated expression in liver and kidney. Two common nonsynonymous SNPs in the Tpcn2 gene strongly associate with blond versus brown hair pigmentation. Diseases associated with TPCN2 include Deafness, Autosomal Recessive 63 and Deafness, Autosomal Recessive 7.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
生物信息学
蛋白别名: Two pore calcium channel protein 2; Two pore channel protein 2; two-pore calcium channel protein 2; Voltage-dependent calcium channel protein TPC2
基因别名: BC025890; D830047E22Rik; SHEP10; TPC2; TPCN2
UniProt ID:(Human) Q8NHX9, (Mouse) Q8BWC0
Entrez Gene ID:(Human) 219931, (Rat) 309139, (Mouse) 233979
参考图片
Expression of Two pore calcium channel protein 2 in rat PC12 cells - Cell surface detection of Two pore calcium channel protein 2 in intact living rat pheochromocytoma (PC12) cells. A. Extracellular staining of cells using Anti-TPCN2 Antibody , (#ACC-072), (1:50), (red). B. Merge of A with the live view of the cell.
Expression of Two pore calcium channel protein 2 in rat cerebellum - Immunohistochemical staining of Two pore calcium channel protein 2 in rat cerebellum using Anti-TPCN2 Antibody (#ACC-072).A. TPCN2 positive cells (green)appear in the granule cell layer (G) of the cerebellum (arrows). B. The extent of the granule layer is demonstrated with the counterstain DAPI (blue).
Western blot analysis of mouse kidney lysate (lanes 1 and 4), rat lung membrane (lanes 2 and 5) and human embryonic Kidney 293 cell lysate (lanes 3 and 6): - 1-3. Anti-TPCN2 Antibody (#ACC-072), (1:200).4-6. Anti-TPCN2 Antibody , preincubated with TPCN2 Blocking Peptide (#BLP-CC072).