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产品详细信息
Reconstitution: 25 µL, 50 µL or 0.2 mL double distilled water (DDW), depending on the sample size. The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20C. The reconstituted solution can be stored at 4C for up to 1 week. For longer periods, small aliquots should be stored at -20C. Avoid multiple freezing and thawing. Centrifuge all antibody preparations before use (10000 x g 5 min).
靶标信息
Scn5a is an integral membrane protein and tetrodotoxin-resistant voltage-gated sodium channel subunit. Scn5a is found primarily in cardiac muscle and is responsible for the initial upstroke of the action potential in an electrocardiogram. Defects in Scn5a are a cause of long QT syndrome type 3 (LQT3), an autosomal dominant cardiac disease. Alternative splicing results in several transcript variants encoding different isoforms of Scn5a. Voltage-gated sodium channesl (VGSCs) mediate regenerative cell membrane depolarization and conduction of electrical signalling in nerves and muscles. Expression of Scn5a is also detected in lymphocytes, glia, and fibroblasts. Further, Scn5a mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, Scn5a forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. Functionally, Scn5a is responsible for the initial upstroke of the action potential and the channel inactivation is regulated by intracellular calcium levels. Voltage-gated sodium channels (NaV) are responsible for action potential initiation and propagation in excitable cells, including nerve, muscle, and neuroendocrine cell types. Scn5a are also expressed at low levels in non-excitable cells, where their physiological role is unclear. Diseases associated with SCN5A include Long Qt Syndrome-3 and Brugada Syndrome 1.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
生物信息学
蛋白别名: cardiac tetrodotoxin-insensitive voltage-dependent sodium channel alpha subunit; CDCD2VF1; CIN5; hH1; HH1CMD1E; LQT3SSS1CMPD2; mH1; RATRSKM2X; RH1; RSkM2; RSKM2X; Scn2x; Sodium channel protein cardiac muscle subunit alpha; Sodium channel protein type 5 subunit alpha; Sodium channel protein type V subunit alpha; sodium channel voltage-gated type V alpha polypeptide; sodium channel, voltage gated, type V alpha subunit; sodium channel, voltage-gated, type 5, alpha subunit; sodium channel, voltage-gated, type V, alpha polypeptide; sodium channel, voltage-gated, type V, alpha subunit; voltage-gated sodium channel Nav1.5c; Voltage-gated sodium channel subunit alpha Nav1.5
基因别名: CDCD2; CMD1E; CMPD2; HB1; HB2; HBBD; HH1; ICCD; IVF; LQT3; mH1; Nav1.5; Nav1.5c; PFHB1; SCAL; SCN5A; SkM1; SkM2; SSS1; VF1
UniProt ID:(Human) E9PEK2, (Rat) P15389, (Mouse) Q9JJV9
Entrez Gene ID:(Human) 6331, (Rat) 25665, (Mouse) 20271
参考图片
Expression of NaV1.5 in rat heart - Immunohistochemical staining of rat heart frozen sections using Guinea pig Anti-NaV1.5 (SCN5A) Antibody (#ASC-005-GP). NaV1.5 staining (red) appears in cardiomyocytes and in intercalated discs (arrows). Nuclei are stained using DAPI (blue).
Western blot analysis of human-NaV1.5 transfected HEK-293 cell lysate (lanes 1 and 3) and rat heart membrane protein (lanes 2 and 4): - 1,2.Guinea pig Anti-NaV1.5 (SCN5A) Antibody (#ASC-005-GP), (1:200).3,4. Guinea pig Anti-NaV1.5 (SCN5A) Antibody , preincubated with Nav1.5/SCN5A (493-511) Blocking Peptide (#BLP-SC005).