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产品详细信息
Reconstitution: 25 µL, 50 µL or 0.2 mL double distilled water (DDW), depending on the sample size. The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20C. The reconstituted solution can be stored at 4C for up to 1 week. For longer periods, small aliquots should be stored at -20C. Avoid multiple freezing and thawing. Centrifuge all antibody preparations before use (10000 x g 5 min).
靶标信息
The sodium channel protein type 8 subunit alpha (Na+ CP type VIII alpha ) is a multi-pass, transmembrane protein that mediates the sodium ion permeability of excitable membranes. The three glycoproteins that comprise the voltage-gated sodium channel proteins include a pore-forming alpha subunit, a noncovalently associated beta1 subunit and a disulfide-linked beta2 subunit. The two beta subunits regulate the level of channel expression, modulate gating and function as cell adhesion molecules for cellular aggregation and cytoskeleton interaction. The alpha subunits of sodium channels type I and III are predominantly expressed in neuronal cell bodies and proximal processes, while type II alpha subunits are more abundant along axons. Sodium channels are important for rapid signal transduction but also play a significant role in neuronal development. Defects of the SCN8A gene have exhibited detrimental effects on the growth of secondary motoneurons. Loss of SCN8A expression will result in progressive paralysis and early death.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
生物信息学
蛋白别名: ataxia 3; hNa6/Scn8a voltage-gated sodium channel; Na+ channel; NaCh6; Peripheral nerve protein type 4; PN4; Scn8a (PN4); Sodium channel 6; Sodium channel protein type 8 subunit alpha; Sodium channel protein type VIII subunit alpha; sodium channel voltage-gated type VIII alpha polypeptide; sodium channel, voltage gated, type VIII alpha subunit; sodium channel, voltage gated, type VIII, alpha subunit; sodium channel, voltage-gated, type 8, alpha polypeptide; sodium channel, voltage-gated, type 8, alpha subunit; sodium channel, voltage-gated, type VIII, alpha polypeptide; Voltage-gated sodium channel subunit alpha Nav1.6; voltage-gated sodium channel type VIII alpha protein
基因别名: AI853486; C630029C19Rik; CERIII; CIAT; dmu; EIEE13; MED; mnd-2; mnd2; NaCh6; Nav1.6; Nbna1; nmf2; nmf335; nmf58; nur14; PN4; SCN8A; seal
UniProt ID:(Human) Q9UQD0, (Mouse) Q9WTU3, (Rat) O88420
Entrez Gene ID:(Human) 6334, (Mouse) 20273, (Rat) 29710
参考图片
Expression of NaV1.6 inrat DRGprimary culture - Immunocytochemical staining of paraformaldehyde-fixed and permeabilized DRG primary culture. A. Staining using Anti-NaV1.6 (SCN8A) Antibody (#ASC-009), (1:200) followed by goat Anti-rabbit-AlexaFluor-555 secondary Antibody . B. Nuclear staining using the cell-permeable dye Hoechst 33342. C. Merged image of panels A and B.
Expression of NaV1.6 in mouse hippocampus - Immunohistochemical staining of mouse hippocampus using Anti-NaV1.6 (SCN8A) Antibody (#ASC-009). A. NaV1.6 (green) is robustly expressed in the CA1 pyramidal layer (white arrows). B. Staining with mouse Anti-parvalbumin (red), a marker of interneurons. C. Merged image of panelsA and Breveals that NaV1.6 appears in some interneurons (arrow) but is not restricted to interneurons. DAPI is used as the counterstain.
Western blot analysis of rat brain membrane: - 1. Anti-NaV1.6 (SCN8A) Antibody (#ASC-009), (1:200).2. Anti-NaV1.6 (SCN8A) Antibody , preincubated with Nav1.6/SCN8A Blocking Peptide (#BLP-SC009).