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KCNN1 (KCA2.1- SK1) ANTIBODY
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产品详细信息
Reconstitution: 25 µL, 50 µL or 0.2 mL double distilled water (DDW), depending on the sample size. The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20C. The reconstituted solution can be stored at 4C for up to 1 week. For longer periods, small aliquots should be stored at -20C. Avoid multiple freezing and thawing. Centrifuge all antibody preparations before use (10000 x g 5 min).
靶标信息
Action potentials in vertebrate neurons are followed by an afterhyperpolarization (AHP) that may persist for several seconds and may have profound consequences for the firing pattern of the neuron. Each component of the AHP is kinetically distinct and is mediated by different calcium-activated potassium channels. The protein encoded by this gene is activated before membrane hyperpolarization and is thought to regulate neuronal excitability by contributing to the slow component of synaptic AHP. The encoded protein is an integral membrane protein that forms a voltage-independent calcium-activated channel with three other calmodulin-binding subunits. KCNN1 is a member of the KCNN family of potassium channels.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
生物信息学
蛋白别名: KCa2.1; potassium intermediate/small conductance calcium-activated channel, subfamily N, member 1; potassium intermediate/small conductance calcium-activated channel, subfamily N, member 1-like; SK1; SKCa 1; SKCa1; Small conductance calcium-activated potassium channel protein 1
基因别名: AI854248; KCa2.1; Kcnn1; SK1
UniProt ID:(Rat) P70606, (Mouse) Q9EQR3
Entrez Gene ID:(Rat) 54261, (Mouse) 84036
参考图片
Expression ofKCa2.1 in rathippocampus. Immunohistochemicalstaining of perfusion-fixed frozen rat brain sections with Anti-KCNN1 (KCa2.1, SK1) Antibody &(8)239; (#APC-039), (1:200), followed by goat Anti-rabbit-AlexaFluor-488. A.Stainingintherat hippocampal CA1 regionshowsKCa2.1immunoreactivity (green)inthe pyramidal cell layer (P) and apical dendrites (arrows).B. Pre-incubation of the Antibody with KCNN1 (KCa2.1, SK1)Blocking Peptide (BLP-PC039), suppressed staining. Cell nuclei are stained with DAPI (blue).
Expression ofKCa2.1 in rat parietal cortex. Immunohistochemicalstaining of perfusion-fixed frozen rat brain sections with Anti-KCNN1 (KCa2.1, SK1) Antibody &(8)239; (#APC-039), (1:200), followed by goat Anti-rabbit-AlexaFluor-488.A.KCa2.1immunoreactivity (green) appearsin outlines of cortical neurons (arrows).B. Pre-incubation of the Antibody with KCNN1 (KCa2.1, SK1)Blocking Peptide (BLP-PC039), suppressed staining. Cell nuclei are stained with DAPI (blue).
Western blot analysisof rat brain cortex: - 1. Anti-KCNN1 (KCa2.1, SK1) Antibody (#APC-039), (1:200).2. Anti-KCNN1 (KCa2.1, SK1) Antibody , preincubated with KCNN1/KCa2.1 Blocking Peptide (#BLP-PC039).