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产品详细信息
Reconstitution: 50 µL double distilled water (DDW), depending on the sample size. The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20C. The reconstituted solution can be stored at 4C, protected from the light, for up to 1 week. For longer periods, small aliquots should be stored at -20C. Avoid multiple freezing and thawing. Centrifuge all antibody preparations before use (10000 X g 5 min).
靶标信息
Tmem119 encodes a single-pass type I transmembrane protein which seems to interact with a multitude of micro-RNAs as well as certain transcription factors such as SMAD1, SMAD5 and RUNX2. Tmem119 has been identified as a surface marker of microglia that can be used to reliably distinguish microglia from infiltrating macrophages. Microglial cells are phagocytes that are restricted to the brain and involved in clearing up debris and dendrite pruning of neurons. They display a high functional plasticity, balancing neuroprotective and neurotoxic functions, which is reflected by their distinct physiology in response to changes in their microenvironment. Microglia are particularly mobile in areas of the brain undergoing restructuring. Reactive microglia co-express the marker Iba1. In a pathological context, microglia have been associated with differentiation of pathogenic/inflammatory A1 type astrocytes by secretion of Cq1, IL-1a and TNF when stimulated with LPS, and thought to contribute to the pathology of several neurodegenerative diseases such as Alzheimers, Parkinsons, Chorea Huntingtons disease and Multiple Sclerosis. The specific function Tmem119 plays on microglial cells remains unclear. Outside of the neural system, Tmem119 seems to be involved in osteoblast differentiation/ossification.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
生物信息学
蛋白别名: OBIF; Osteoblast induction factor; Transmembrane protein 119; transmembrane protein 119 homolog
基因别名: AW208946; BC025600; obif; RGD1307573; Tmem119
UniProt ID:(Mouse) Q8R138
Entrez Gene ID:(Mouse) 231633, (Rat) 304581
参考图片
Cell surface detection of TMEM119 by direct flow cytometry in live intact mouse BV-2 microglia cells: - (black) Cells (red) Cells + Rabbit IgG Isotype Control-FITC. (green) Cells + Anti-TMEM119 (extracellular)-FITC Antibody (ANR-175-F), 2.5 µg.