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SLO BETA 4 (KCNMB4) ANTIBODY
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产品详细信息
Reconstitution: 25 µL, 50 µL or 0.2 mL double distilled water (DDW), depending on the sample size. The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20C. The reconstituted solution can be stored at 4C for up to 1 week. For longer periods, small aliquots should be stored at -20C. Avoid multiple freezing and thawing. Centrifuge all antibody preparations before use (10000 x g 5 min).
靶标信息
MaxiK channels are large conductance, voltage and calcium-sensitive potassium channels which are fundamental to the control of smooth muscle tone and neuronal excitability. MaxiK channels can be formed by 2 subunits: the pore-forming alpha subunit and the modulatory beta subunit. The protein encoded by this gene is an auxiliary beta subunit which slows activation kinetics, leads to steeper calcium sensitivity, and shifts the voltage range of current activation to more negative potentials than does the beta 1 subunit.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
生物信息学
蛋白别名: big potassium channel beta subunit 4; BK channel beta subunit 4; BK channel subunit beta-4; BKbeta4; calcium activated potassium channel beta 4 subunit; Calcium-activated potassium channel subunit beta-4; Calcium-activated potassium channel, subfamily M subunit beta-4; Charybdotoxin receptor subunit beta-4; hbeta4; K(VCA)beta-4; KCMB4; large conductance calcium-dependent potassium ion channel beta 4 subunit; Maxi K channel subunit beta-4; MaxiK channel beta-subunit 4; potassium channel subfamily M regulatory beta subunit 4; potassium large conductance calcium-activated channel, subfamily M, beta member 4; Slo-beta-4; Slowpoke beta 4
基因别名: 1700058G18Rik; 2900045G12Rik; KCNMB4
UniProt ID:(Human) Q86W47, (Rat) Q9ESK8, (Mouse) Q9JIN6
Entrez Gene ID:(Human) 27345, (Rat) 66016, (Mouse) 58802
参考图片
Expression of KCNMB4in rat hippocampus and cortex - Immunohistochemical staining of perfusion-fixed frozen rat brain sections with Anti-slo beta 4 (KCNMB4) Antibody (#APC-061), (1:200), followed by goat- Anti-rabbit-AlexaFluor-488. A. KCNMB4staining (green)in rat hippocampal CA1 region is detected inapical dendrites (arrows) of pyramidal neurons from the pyramidal layer (PL). B. Staining in rat parietal cortex shows staining of apical dendrites (arrows) of pyramidal neurons. Cell nuclei are stained with DAPI (blue).
Western blot analysisof rat brain membranes: - 1. Anti-slo beta 4 (KCNMB4) Antibody (#APC-061), (1:200). 2. Anti-slo beta 4 (KCNMB4) Antibody , preincubated with slo beta 4/KCNMB4 Blocking Peptide (#BLP-PC061).