P2X4 RECEPTOR (EXTRACELLULAR)

1/2

P2X4 RECEPTOR (EXTRACELLULAR)

品牌： Thermo

下载产品说明书

下载SDS

用小程序，查商品更便捷

对比

咨询

产品介绍

产品信息

应用

建议稀释比

已发表文章

流式细胞分析 (Flow)

2.5 µg

产品规格

种属反应

Human,Mouse,Rat

宿主/亚型

Rabbit / IgG

分类

Polyclonal

类型

Antibody

抗原

(C)RDLAGKEQRTLTK, corresponding to amino acid residues 301-313 of rat P2X4 receptor, Extracellular

查看免疫原

偶联物

FITC FITC FITC

激发/发射光谱

498/517 nm 查看光谱

形式

Lyophilized

浓度

1 mg/mL

纯化类型

Antigen affinity chromatography

保存液

PBS, pH 7.4, with 1% BSA

内含物

0.05% sodium azide

保存条件

-20° C, Avoid Freeze/Thaw Cycles, store in dark

运输条件

Ambient (domestic); Wet ice (international)

产品详细信息

Reconstitution: 50 µL double distilled water (DDW), depending on the sample size. The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20C. The reconstituted solution can be stored at 4C for up to 1 week. For longer periods, small aliquots should be stored at -20C. Avoid multiple freezing and thawing. Centrifuge all antibody preparations before use (10000 x g 5 min).

靶标信息

The product of this gene belongs to the family of purinoceptors for ATP. This receptor functions as a ligand-gated ion channel with high calcium permeability. The main pharmacological distinction between the members of the purinoceptor family is the relative sensitivity to the antagonists suramin and PPADS. The product of this gene has the lowest sensitivity for these antagonists. Multiple alternatively spliced transcript variants have been identified for this gene although their full-length natures have not been determined.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

生物信息学

蛋白别名: ATP receptor; ATP-gated cation channel protein; ionotropic purinergic receptor; P2X purinoceptor 4; P2X receptor, subunit 4; P2X4; Purinergic receptor; purinergic receptor P2X, ligand gated ion channel, 4; purinergic receptor P2X, ligand-gated ion channel, 4; purinergic receptor P2X4; purinergic receptor P2x4 subunit variant e; purinoceptor P2X4

查看更多收起

基因别名: AI504491; AW555605; D5Ertd444e; P2RX4; P2X4; P2X4R

查看更多收起

UniProt ID:(Human) Q99571, (Rat) P51577

查看更多收起

Entrez Gene ID:(Human) 5025, (Mouse) 18438, (Rat) 29659

查看更多收起

功能

purinergic nucleotide receptor activity extracellular ATP-gated cation channel activity receptor binding copper ion binding protein binding ATP binding drug binding zinc ion binding protein homodimerization activity cadherin binding ion channel activity ligand-gated ion channel

参与通路

tissue homeostasis regulation of sodium ion transport transport signal transduction blood coagulation regulation of blood pressure positive regulation of calcium ion transport into cytosol negative regulation of cardiac muscle hypertrophy neuronal action potential sensory perception of pain positive regulation of prostaglandin secretion response to ATP ion transmembrane transport response to fluid shear stress purinergic nucleotide receptor signaling pathway endothelial cell activation positive regulation of nitric oxide biosynthetic process positive regulation of calcium-mediated signaling protein homooligomerization membrane depolarization positive regulation of calcium ion transport regulation of cardiac muscle contraction relaxation of cardiac muscle cellular response to ATP apoptotic signaling pathway cation transmembrane transport nitric oxide biosynthetic process ion transport calcium ion transport vasodilation excitatory postsynaptic potential

参考图片

Cell surface detection of P2RX4 in live intact human THP-1 monocytic leukemia cells: - (black line) cells. (red) Cells + rabbit IgG isotype control-FITC. (green) Cells + Anti-P2X4 Receptor (extracellular)-FITC Antibody (#APR-024-F), (2.5 µg).

Cell surface detection of P2RX4 in live intact mouse BV-2 microglia cells: - (black line) cells. (red) Cells + rabbit IgG isotype control-FITC. (green) Cells + Anti-P2X4 Receptor (extracellular)-FITC Antibody (#APR-024-F), (2.5 µg).

声明：本官网所有报价均为常温或者蓝冰运输价格，如有产品需要干冰运输，需另外加收干冰运输费。

货号：

APR-024-F-50UL-Thermo

一键复制

询价

50UL

选择数量

当前规格1件起购

配送至

预计4-6周送达，快递: 免运费，若需干冰额外收费

询价大包装询价