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靶标信息
This gene encodes a protein with a conserved RNA-binding motif. The protein is found predominantly in the nucleus, although it is also present in the cytoplasm. It is preferentially associated with mRNAs produced by splicing, including both nuclear mRNAs and newly exported cytoplasmic mRNAs. It is thought that the protein remains associated with spliced mRNAs as a tag to indicate where introns had been present, thus coupling pre- and post-mRNA splicing events. Previously, it was thought that two genes encode this protein, RBM8A and RBM8B; it is now thought that the RBM8B locus is a pseudogene. Two alternative start codons result in two forms of the protein, and this gene also uses multiple polyadenylation sites.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
生物信息学
蛋白别名: Binder of OVCA1-1; BOV-1; BOV1; BOV1A; BOV1B; BOV1C; ribonucleoprotein RBM8; Ribonucleoprotein RBM8A; RNA binding motif protein 8B; rna-binding; RNA-binding motif protein 8A; RNA-binding protein 8A; RNA-binding protein Y14
基因别名: BOV-1A; BOV-1B; BOV-1C; C1DELq21.1; DEL1q21.1; HSPC114; MDS014; RBM8; RBM8A; RBM8B; TAR; Y14; ZNRP; ZRNP1
UniProt ID:(Human) Q9Y5S9
Entrez Gene ID:(Human) 9939
参考图片
Immunocytochemistry/Immunofluorescence analysis of PFA-fixed HeLa cells using Y14, RBM8A Monoclonal Antibody (Product # 9939-MSM2-P1ABX) followed by goat anti-mouse IgG-CF488 (green). CF640A phalloidin (red)..
Flow Cytometry analysis of PFA-fixed HeLa cells using Y14, RBM8A Monoclonal Antibody (Product # 9939-MSM2-P1ABX) followed by goat anti-mouse IgG-CF488 (blue); unstained cells (red).
Analysis of Protein Array containing more than 19,000 full-length human proteins Y14, RBM8A Monoclonal Antibody (Product # 9939-MSM2-P1ABX). Z- and S- Score: The Z-score represents the strength of a signal that a monoclonal antibody (MAb) (in combination with a fluorescently-tagged anti-IgG secondary antibody) produces when binding to a particular protein on the HuProtTM array. Z-scores are described in units of standard deviations (SD's) above the mean value of all signals generated on that array. If targets on HuProtTM are arranged in descending order of the Z-score, the S-score is the difference (also in units of SD's) between the Z-score. S-score therefore represents the relative target specificity of a MAb to its intended target. A MAb is considered to specific to its intended target, if the MAb has an S-score of at least 2.5. For example, if a MAb binds to protein X with a Z-score of 43 and to protein Y with a Z-score of 14, then the S-score for the binding of that MAb to protein X is equal to 29.