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Immunohistochemistry (PFA fixed): incubate antibody for 30 min RT. Staining of formalin-fixed tissues requires heating tissue sections in 10mM Tris with 1mM EDTA, pH 9.0, for 45 min at 95 degrees C followed by cooling at RT for 20 minutes.
靶标信息
Calponin, a thin filament associated protein is implicated in the regulation and modulation of smooth muscle contraction. It is capable of binding to actin, calmodulin, troponin C and tropomyosin. Calponin is expressed in smooth muscle and tissues containing significant amounts of smooth muscle. Two isoforms of calponin exist whose molecular weights are 34kDa and 29kDa. Expression of the 29kDa form is primarily restricted to muscle of the urogenital tract. The expression of calponin has also been demonstrated in myoepithelial cells from benign and malignant breast lesions. It stains smooth muscle, myoepithelial cells, myofibroblasts, keratinocytes and nerve fibers. It identifies myoepithelial cells in breast lesions, and helps differentiate breast collagenous spherulosis (positive) from adenoid cystic carcinoma. Adenoid cystic carcinoma in salivary gland tumors is calponin positive.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
生物信息学
蛋白别名: Basic calponin; calponin 1, basic, smooth muscle; calponin 1, smooth muscle; Calponin H1, smooth muscle; Calponin-1; calponins, basic; epididymis secretory protein Li 14
基因别名: CNN1; HEL-S-14; Sm-Calp; SMCC
UniProt ID:(Human) P51911, (Rat) Q08290
Entrez Gene ID:(Human) 1264, (Rat) 65204
参考图片
Immunocytochemistry/Immunofluorescence analysis of Human K562 cells using Calponin-1 Recombinant Monoclonal Antibody (Product # 1264-RBM4-P1) followed by goat anti-rabbit IgG-CF488 (Green). The nuclear counterstain is Reddot (Red).
Immunohistochemistry (Paraffin) analysis performed in formalin fixed, paraffin-embedded human uterus using Calponin-1 Recombinant Monoclonal Antibody (Product # 1264-RBM4-P1).
Immunohistochemistry (Paraffin) analysis performed in formalin fixed, paraffin-embedded rat uterus using Calponin-1 Recombinant Monoclonal Antibody (Product # 1264-RBM4-P1).
Flow Cytometry analysis of PFA-fixed K562 cells using Calponin-1 Recombinant Monoclonal Antibody (Product # 1264-RBM4-P1) followed by Goat anti-Rabbit- IgG-CF488 (Blue); Isotype Control (Red).
SDS-PAGE Analyis Purified Calponin-1 Recombinant Monoclonal Antibody (Product # 1264-RBM4-P1). Confirmation of Purity and Integrity of Antibody.