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产品详细信息
Reconstitution: 25 µL, 50 µL or 0.2 mL double distilled water (DDW), depending on the sample size. The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20C. The reconstituted solution can be stored at 4C for up to 1 week. For longer periods, small aliquots should be stored at -20C. Avoid multiple freezing and thawing. Centrifuge all antibody preparations before use (10000 x g 5 min).
靶标信息
Piezo1 is a pore-forming subunit of a mechanosensitive non-specific cation channel, and generates currents characterized by a linear current-voltage relationship that are sensitive to ruthenium red and gadolinium. Structurally, Piezo1 contains 36 transmembrane domains and functions as a homotetramer. Piezo1 plays a key role in epithelial cell adhesion by maintaining integrin activation through R-Ras recruitment to the ER, most probably in its activated state, and subsequent stimulation of calpain signaling. In the kidney, Piezo1 may contribute to the detection of intraluminal pressure changes and to urine flow sensing. Piezo1 acts as shear-stress sensor that promotes endothelial cell organization and alignment in the direction of blood flow through calpain activation and plays a key role in blood vessel formation and vascular structure in both development and adult physiology. The protein encoded by the Piezo1 gene is a mechanically-activated ion channel that links mechanical forces to biological signals. Defects in this gene have been associated with dehydrated hereditary stomatocytosis. Diseases associated with PIEZO1 include Dehydrated Hereditary Stomatocytosis with/without Pseudohyperkalemia And/Or Perinatal Edema and Lymphedema.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
生物信息学
蛋白别名: family with sequence similarity 38, member A; Membrane protein induced by beta-amyloid treatment; Mib; Piezo-type mechanosensitive ion channel component 1; Protein FAM38A; protein PIEZO1
基因别名: 9630020g22; Fam38a; Mib; mKIAA0233; Piezo1
UniProt ID:(Rat) Q0KL00
Entrez Gene ID:(Rat) 361430, (Mouse) 234839
参考图片
Expression of Piezo1 in rat olfactory bulb - Immunohistochemical staining of rat olfactory bulb sections using Anti-Piezo1 Antibody (#APC-087). A. Piezo1 staining (green) appears in the neuropil with varying intensity with in and between glomeruli. B. Nuclear staining (blue) using DAPI as the counterstain. C. Merged image of panels A and B.
Western blot analysis of rat lung (lanes 1 and 3) and mouse lung (lanes 2 and 4) lysates: - 1,2. Anti-Piezo1 Antibody (#APC-087), (1:600).3,4. Anti-Piezo1 Antibody , preincubated with Piezo1 Blocking Peptide (#BLP-PC087).