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产品详细信息
Reconstitution: 50 µL double distilled water (DDW), depending on the sample size. The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20C. The reconstituted solution can be stored at 4C for up to 1 week. For longer periods, small aliquots should be stored at -20C. Avoid multiple freezing and thawing. Centrifuge all antibody preparations before use (10000 x g 5 min).
靶标信息
The mammalian transient receptor potential (TRP) superfamily can be divided into three major families including the "canonical TRP" (TRPC) family. The seven members of this family share the activation through PLC-coupled receptors and have been suggested to be components of receptor-regulated cation channels in different cell types. Furthermore, the members of the TRPC3/6/7 subfamily can be activated by diacylglycerol analogs, suggesting a possible mechanism of activation of these channels by PLC-coupled receptors. TRPC3 encodes a Ca2+-permeant channel that is agonist-activated but not store-operated or directly receptor-activated. TRPC3 physically interacts with TRPC6 and TRPC7 and forms functional tetrameric channels.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
生物信息学
蛋白别名: hTrp-3; hTrp3; ion channel protein; mTrp3; Receptor-activated cation channel TRP3; Short transient receptor potential channel 3; transient receptor potential cation channel subfamily C member 3; transient receptor potential cation channel subfamily C member 3 variant c; transient receptor potential cation channel, subfamily C, member 3; Transient receptor protein 3; TRP-3; Trp-related protein 3; TrpC3
基因别名: Mwk; SCA41; Trcp3; TRP3; TRPC3; TrpC3c; Trrp3
UniProt ID:(Human) Q13507, (Mouse) Q9QZC1
Entrez Gene ID:(Human) 7222, (Rat) 60395, (Mouse) 22065
参考图片
Expression of TRPC3 in rat DRG - Immunohistochemical staining of rat dorsal root ganglion (DRG) frozen sections using Anti-TRPC3-ATTO Fluor-594 Antibody (#ACC-016-AR), (1:50). Staining is present in neuronal cell bodies. Hoechst 33342 is used as the counterstain.
Colocalization of TRPC6 and TRPC3 in rat cerebellum - Immunohistochemical staining of rat cerebellum frozen section using Guinea pig Anti-TRPC6 Antibody (#ACC-017-GP) and rabbit Anti-TRPC3-ATTO Fluor-594 Antibody (#ACC-016-AR). A. TRPC6 staining (green) appears in molecular layer and in Purkinje cells. B. In the same section as in A, staining of TRPC3 (red) appears as well in both molecular layer and Purkinje cells. C. Merge images of A and B indicates co-localization in Purkinje cells and molecular layer.
Multiplex staining of VMAT2 and TRPC3 in rat brain - Immunohistochemical staining of perfusion-fixed frozen rat substantia nigra sections using Anti-VMAT2-ATTO Fluor-488 Antibody (#AMT-006-AG), (1:60) and Anti-TRPC3-ATTO Fluor-594 Antibody (#ACC-016-AR), (1:60). A. VMAT2 staining (green). B. The same section stained for TRPC3 (red). C. Merged image demonstrates the ubiquitous colocalization of VMAT2 and TRPC3 in cells of the substantia nigra pars compacta. Arrows point at examples of co-expression.