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ADENOSINE A2A RECEPTOR ANTIBOD
ADENOSINE A2A RECEPTOR ANTIBOD
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ADENOSINE A2A RECEPTOR ANTIBOD

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品牌： Thermo
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免疫印迹 (WB)

1:200
-

免疫组化（石蜡） (IHC (P))

1:50
-
产品规格

种属反应

Human,Mouse,Rat

宿主/亚型

Rabbit / IgG

分类

Polyclonal

类型

Antibody

抗原

(C)RQLKQMESQPLPGER, corresponding to amino acid residues 201-215 of mouse adenosine A2Areceptor, 3rd intracellular loop
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偶联物

Unconjugated Unconjugated Unconjugated

形式

Lyophilized

浓度

0.75 mg/mL

纯化类型

Antigen affinity chromatography

保存液

PBS, pH 7.4, with 1% BSA

内含物

0.05% sodium azide

保存条件

-20° C, Avoid Freeze/Thaw Cycles

运输条件

Ambient (domestic); Wet ice (international)

产品详细信息

Reconstitution: 25 µL, 50 µL or 0.2 mL double distilled water (DDW), depending on the sample size. The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20C. The reconstituted solution can be stored at 4C for up to 1 week. For longer periods, small aliquots should be stored at -20C. Avoid multiple freezing and thawing. Centrifuge all antibody preparations before use (10000 x g 5 min).

靶标信息

ADORA2A is a protein which is one of several receptor subtypes for adenosine. The activity of the encoded protein, a G-protein coupled receptor family member, is mediated by G proteins which activate adenylyl cyclase. This protein is abundant in basal ganglia, vasculature and platelets and it is a major target of caffeine.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

生物信息学

蛋白别名: A2a receptor; Adenosine A2a-receptor; Adenosine receptor A2a; adenosine receptor subtype A2a; AR; hA2aR

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基因别名: A2AAR; A2aR; AA2AR; ADENO; ADORA2; ADORA2A; Adora2l1; RDC8

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UniProt ID:(Human) P29274, (Mouse) Q60613, (Rat) P30543

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Entrez Gene ID:(Human) 135, (Mouse) 11540, (Rat) 25369

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功能
G-protein coupled adenosine receptor activity protein binding enzyme binding identical protein binding signal transducer activity G-protein coupled receptor activity type 5 metabotropic glutamate receptor binding protein heterodimerization activity alpha-actinin binding G-protein coupled receptor
参与通路
adenosine receptor signaling pathway cAMP biosynthetic process phagocytosis apoptotic process inflammatory response cellular defense response adenylate cyclase-modulating G-protein coupled receptor signaling pathway cell-cell signaling central nervous system development blood coagulation sensory perception blood circulation positive regulation of adenylate cyclase activity involved in G-protein coupled receptor signaling pathway cellular protein metabolic process synaptic transmission, dopaminergic response to amphetamine regulation of transcription, DNA-templated negative regulation of protein kinase activity signal transduction G-protein coupled receptor signaling pathway adenylate cyclase-activating G-protein coupled receptor signaling pathway protein kinase C-activating G-protein coupled receptor signaling pathway synaptic transmission, cholinergic locomotory behavior negative regulation of cell proliferation positive regulation of glutamate secretion positive regulation of acetylcholine secretion, neurotransmission regulation of norepinephrine secretion positive regulation of cAMP biosynthetic process response to caffeine positive regulation of synaptic transmission, GABAergic synaptic transmission, glutamatergic positive regulation of urine volume positive regulation of renal sodium excretion negative regulation of locomotion vasodilation eating behavior negative regulation of vascular permeability negative regulation of cysteine-type endopeptidase activity involved in apoptotic process response to alkaloid negative regulation of neuron apoptotic process positive regulation of circadian sleep/wake cycle, sleep negative regulation of alpha-beta T cell activation astrocyte activation regulation of synaptic plasticity neuron projection morphogenesis positive regulation of protein secretion negative regulation of inflammatory response regulation of mitochondrial membrane potential membrane depolarization regulation of calcium ion transport positive regulation of synaptic transmission, glutamatergic excitatory postsynaptic potential inhibitory postsynaptic potential prepulse inhibition positive regulation of apoptotic signaling pathway response to drug

参考图片

Expression of AdenosineA2AReceptorin rat lung - Immunohistochemical staining of paraffin embedded rat lung sections using Anti-AdenosineA2AReceptor Antibody (#AAR-002), (1:50). A2aR is expressed in the respiratory epithelium of the bronchiole (Br). Note that smooth muscle and endothelium in blood vessels are negative. Hematoxilin is used as the counterstain.

Expression of AdenosineA2AReceptorinmouse diagonal band - Immunohistochemical staining of mouse diagonal band using Anti-AdenosineA2AReceptor Antibody (#AAR-002). A2aR (green) appears in the brocaof individual neurons (arrows) and in neuropil (asterisk).DAPI is used as the counterstain.

Western blot analysis of rat aortic endothelial cells (lanes 1, 3), rat brain (lanes 2, 4) and Jurkat (lanes 5, 6) lysates: - 1,2,5. Anti-AdenosineA2AReceptor Antibody (#AAR-002), (1:200).3,4,6. Anti-Adenosine A2AReceptor Antibody , preincubated with Adenosine A2A Receptor Blocking Peptide (#BLP-AR002).

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货号：
AAR-002-200UL
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200UL
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