全部商品分类
下载产品说明书
用小程序，查商品更便捷
收藏
对比
咨询种属反应
宿主/亚型
分类
类型
抗原
偶联物
形式
浓度
纯化类型
保存液
内含物
保存条件
运输条件
产品详细信息
Reconstitution: 25 µL, 50 µL or 0.2 mL double distilled water (DDW), depending on the sample size. The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20C. The reconstituted solution can be stored at 4C for up to 1 week. For longer periods, small aliquots should be stored at -20C. Avoid multiple freezing and thawing. Centrifuge all antibody preparations before use (10000 x g 5 min).
靶标信息
LYNX1 acts in different tissues through interaction to nicotinic acetylcholine receptors (nAChRs). The proposed role as modulator of nAChR activity seems to be dependent on the nAChR subtype and stoichiometry, and to involve an effect on nAChR trafficking and its cell surface expression, and on single channel properties of the nAChR inserted in the plasma membrane. Modulates functional properties of nicotinic acetylcholine receptors (nAChRs) to prevent excessive excitation, and hence neurodegeneration. Enhances desensitization by increasing both the rate and extent of desensitization of alpha-4:beta-2-containing nAChRs and slowing recovery from desensitization. Promotes large amplitude ACh-evoked currents through alpha-4:beta-2 nAChRs. Is involved in regulation of the nAChR pentameric assembly in the endoplasmic reticulum. Shifts stoichiometry from high sensitivity alpha-4(2):beta-2(3) to low sensitivity alpha-4(3):beta-2(2) nAChR. In vitro modulates alpha-3:beta-4-containing nAChRs. Reduces cell surface expression of (alpha-3:beta-4)(2):beta-4 and (alpha-3:beta-4)(2):alpha-5 nAChRs suggesting an interaction with nAChR alpha-3(-):(+)beta-4 subunit interfaces and an allosteric mode. Corresponding single channel effects characterized by decreased unitary conductance, altered burst proportions and enhanced desensitization/inactivation seem to depend on nAChR alpha:alpha subunit interfaces and are greater in (alpha-3:beta-2)(2):alpha-3 when compared to (alpha-3:beta-2)(2):alpha-5 nAChRs. Prevents plasticity in the primary visual cortex late in life.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
生物信息学
蛋白别名: Endogenous prototoxin LYNX1; GC26; Ly-6 neurotoxin-like protein 1; Ly-6/neurotoxin-like protein 1; secreted Ly-6/uPAR domain-containing protein 2; secreted Ly-6/uPAR-related protein 2; secreted Ly6/uPAR related protein 2; SLURP-2; Testicular tissue protein Li 112
基因别名: AI838844; LYNX1; SLURP-2; SLURP2
UniProt ID:(Human) P0DP58, (Mouse) P0DP60
Entrez Gene ID:(Human) 66004, (Mouse) 23936, (Rat) 300018
参考图片
Expression of Lynx1 in rat dorsal raphe nucleus and substantia nigra pars compacta - Immunohistochemical staining of perfusion-fixed frozen rat brain sections with Anti-Lynx1 (extracellular) Antibody (#ANC-021), (1:1000), followed by goat Anti-rabbit-AlexaFluor-488. A. Lynx1 staining in the dorsal raphe nucleus (DRN), (green) is detected in cells of the medial DRN (MDRN, horizontal arrows) and in cells of the lateral DRN (LDRN), (vertical arrows). B. Lynx1 immunoreactivity in the substantia nigra pars compacta (SNC), (green) is observed in cells of the SNC (arrows). Cell nuclei are stained with DAPI (blue).
Western blot analysis of human THP-1 monocytic leukemia cell line lysate (lanes 1 and 3) and human Jurkat T-cell leukemia cell line lysate (lanes 2 and 4): - 1, 2. Anti-Lynx1 (extracellular) Antibody (#ANC-021), (1:200). 3, 4. Anti-Lynx1 (extracellular) Antibody , preincubated with Lynx1 (extracellular) Blocking Peptide (#BLP-NC021).
Western blot analysis of rat brain lysate (lanes 1 and 3) and mouse brain lysate (lanes 2 and 4): - 1, 2. Anti-Lynx1 (extracellular) Antibody (#ANC-021), (1:200). 3, 4. Anti-Lynx1 (extracellular) Antibody , preincubated with Lynx1 (extracellular) Blocking Peptide (#BLP-NC021).
Cell surface detection of Lynx1 in live intact human THP-1 monocytic leukemia cells: - (black line) cells. (red) Cells + goat- Anti-rabbit-FITC. (green) Cells + Anti-Lynx1 (extracellular) Antibody (#ANC-021), (2.5 µg) + goat- Anti-rabbit-FITC.