老带新
首页
P2X7 RECEPTOR (EXTRACELLULAR)
P2X7 RECEPTOR (EXTRACELLULAR)
1/2

P2X7 RECEPTOR (EXTRACELLULAR)

分享
品牌： Thermo
pdf 下载产品说明书
pdf 下载SDS
用小程序，查商品更便捷
收藏
对比对比
咨询咨询
产品介绍
产品介绍
产品信息
应用
建议稀释比
已发表文章

免疫细胞化学 (ICC/IF)

1:25
-

流式细胞分析 (Flow)

10 µg/1x10^6 cells
-
产品规格

种属反应

Human,Mouse,Rat

宿主/亚型

Rabbit / IgG

分类

Polyclonal

类型

Antibody

抗原

KKGWMDPQSKGIQTGRC, corresponding to amino acid residues 136-152 of mouse P2X7 receptor, Extracellular loop
查看免疫原

偶联物

Atto™ 488 Atto™ 488 Atto™ 488

激发/发射光谱

501/523 nm

形式

Lyophilized

浓度

1 mg/mL

纯化类型

Antigen affinity chromatography

保存液

PBS, pH 7.4, with 1% BSA

内含物

0.05% sodium azide

保存条件

-20° C, Avoid Freeze/Thaw Cycles

运输条件

Ambient (domestic); Wet ice (international)

产品详细信息

Reconstitution: 50 µL double distilled water (DDW), depending on the sample size. The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20C. The reconstituted solution can be stored at 4C for up to 1 week. For longer periods, small aliquots should be stored at -20C. Avoid multiple freezing and thawing. Centrifuge all antibody preparations before use (10000 x g 5 min).

靶标信息

The product of this gene belongs to the family of purinoceptors for ATP. This receptor functions as a ligand-gated ion channel and is responsible for ATP-dependent lysis of macrophages through the formation of membrane pores permeable to large molecules. Activation of this nuclear receptor by ATP in the cytoplasm may be a mechanism by which cellular activity can be coupled to changes in gene expression. Multiple alternatively spliced variants have been identified, most of which fit nonsense-mediated decay criteria.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

生物信息学

蛋白别名: ATP receptor; MGC20089; P2X purinoceptor 7; p2X receptor 7; P2X7; P2X7 purinoceptor; P2X7 receptor; P2Z; P2Z receptor; Purinergic receptor; purinergic receptor P2X, ligand gated ion channel, 7; purinergic receptor P2X, ligand-gated ion channel, 7; purinergic receptor P2X7; purinergic receptor P2X7 variant A

查看更多 收起

基因别名: AI467586; P2RX7; P2X(7); P2X7; P2X7R

查看更多 收起

UniProt ID:(Human) Q99572, (Rat) Q64663, (Mouse) Q9Z1M0

查看更多 收起

Entrez Gene ID:(Human) 5027, (Rat) 29665, (Mouse) 18439

查看更多 收起

功能
lipopolysaccharide binding purinergic nucleotide receptor activity extracellular ATP-gated cation channel activity receptor binding protein binding ATP binding protein homodimerization activity magnesium ion binding receptor activity copper ion binding zinc ion binding channel activity protein serine/threonine kinase activator activity scaffold protein binding ion channel activity ligand-gated ion channel
参与通路
activation of MAPK activity cell morphogenesis phagolysosome assembly positive regulation of T cell mediated cytotoxicity regulation of sodium ion transport protein phosphorylation membrane protein ectodomain proteolysis phospholipid transfer to membrane membrane budding inflammatory response mitochondrion organization cell surface receptor signaling pathway blood coagulation response to mechanical stimulus response to zinc ion positive regulation of calcium ion transport into cytosol positive regulation of gene expression positive regulation of glutamate secretion positive regulation of gamma-aminobutyric acid secretion synaptic vesicle exocytosis protein processing phospholipid scrambling sensory perception of pain cytolysis positive regulation of bone mineralization cellular response to extracellular stimulus bleb assembly positive regulation of prostaglandin secretion response to lipopolysaccharide positive regulation of interleukin-6 production collagen metabolic process response to ATP response to fluid shear stress positive regulation of ion transmembrane transport purinergic nucleotide receptor signaling pathway T cell proliferation response to drug T cell homeostasis NAD transport negative regulation of MAPK cascade multicellular organismal protein catabolic process phospholipid translocation negative regulation of bone resorption negative regulation of cell volume positive regulation of glycolytic process positive regulation of cytolysis ceramide biosynthetic process pore complex assembly skeletal system morphogenesis homeostasis of number of cells within a tissue positive regulation of interleukin-1 alpha secretion positive regulation of interleukin-1 beta secretion defense response to Gram-positive bacterium release of sequestered calcium ion into cytosol protein oligomerization positive regulation of cytoskeleton organization response to calcium ion response to electrical stimulus regulation of killing of cells of other organism membrane depolarization positive regulation of mitochondrial depolarization positive regulation of lymphocyte apoptotic process cellular response to dsRNA reactive oxygen species metabolic process apoptotic signaling pathway extrinsic apoptotic signaling pathway positive regulation of bleb assembly positive regulation of protein phosphorylation cation transport calcium ion transport cell volume homeostasis plasma membrane organization response to bacterium response to organic substance gene expression programmed cell death response to organic cyclic compound organic cation transport neuronal action potential positive regulation of interleukin-1 beta production positive regulation of apoptotic process positive regulation of catalytic activity positive regulation of MAPK cascade positive regulation of ossification positive regulation of protein secretion positive regulation of cytokine secretion cellular response to organic cyclic compound cation transmembrane transport transport ion transport

参考图片

Expression of P2RX7 in HEK-293 transfected cells - Cell surface detection of P2RX7 in live intact P2X7-HEK-293 transfected cells. Extracellular staining of cells using Anti-P2X7 Receptor (extracellular)-ATTO Fluor-488 Antibody (#APR-008-AG), (green), (1:25).

Cell surface detection of P2RX7 in intact living Jurkat cells: - (black) Unstained cells. (red) Cells + Anti-P2X7 Receptor (extracellular)-ATTO Fluor-488 Antibody (#APR-008-AG), (10 µg/1x106 cells).

声明 ：本官网所有报价均为常温或者蓝冰运输价格，如有产品需要干冰运输，需另外加收干冰运输费。
货号：
APR-008-AG-50UL-Thermo
一键复制
询价
50UL
选择数量
当前规格1件起购 
配送至
预计4-6周送达，快递: 免运费，若需干冰额外收费
询价 大包装询价