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产品详细信息
Reconstitution: 25 µL, 50 µL or 0.2 mL double distilled water (DDW), depending on the sample size. The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20C. The reconstituted solution can be stored at 4C for up to 1 week. For longer periods, small aliquots should be stored at -20C. Avoid multiple freezing and thawing. Centrifuge all antibody preparations before use (10000 x g 5 min).
靶标信息
CHRNA3 locus encodes a member of the nicotinic acetylcholine receptor family of proteins. Members of this family of proteins form pentameric complexes comprised of both alpha and beta subunits. This locus encodes an alpha-type subunit, as it contains characteristic adjacent cysteine residues. The encoded protein is a ligand-gated ion channel that likely plays a role in neurotransmission. Polymorphisms in this gene have been associated with an increased risk of smoking initiation and an increased susceptibility to lung cancer. Alternatively spliced transcript variants have been described.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
生物信息学
蛋白别名: acetylcholine receptor; Acetylcholine receptor alpha 3 (neuronal nicotine); alpha 3; cetylcholine receptor alpha 3 (neuronal nicotine); cholinergic receptor; cholinergic receptor nicotinic alpha polypeptide 4; cholinergic receptor, nicotinic, alpha polypeptide 3; nAChR alpha 3; Neuronal acetylcholine receptor subunit alpha-3; neuronal nicotinic acetylcholine receptor, alpha 3 subunit
基因别名: (a)3; A730007P14Rik; Acra-3; Acra3; Chrna3
UniProt ID:(Mouse) Q8R4G9
Entrez Gene ID:(Mouse) 110834, (Rat) 25101
参考图片
Expression of Nicotinic acetylcholine receptor alpha 3 in rat neocortex - Immunohistochemical staining of immersion-fixed, free floating rat brain frozen sections were stained using Anti-Nicotinic Acetylcholine Receptor alpha 3 (CHRNA3) (extracellular) Antibody (#ANC-003), (1:200). A. Intense staining (green) of nAChR alpha 3 appears in apical dendrites (thin arrows). A few cortical interneurons (thick arrow) are also stained with the Antibody . B. The same section was stained also for parvalbumin (red staining). An arrow depicts a neuron expressing both nAChR alpha 3 and parvalbumin.
Western blot analysis of rat brain membranes: - 1. Anti-Nicotinic Acetylcholine Receptor alpha 3 (CHRNA3) (extracellular) Antibody (#ANC-003), (1:200). 2. Anti-Nicotinic Acetylcholine Receptor alpha 3 (CHRNA3) (extracellular) Antibody , preincubated with Nicotinic Acetylcholine Receptor alpha 3/CHRNA3 (extracellular) Blocking Peptide (#BLP-NC003).