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P2X7 RECEPTOR (EXTRACELLULAR)
P2X7 RECEPTOR (EXTRACELLULAR)
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P2X7 RECEPTOR (EXTRACELLULAR)

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品牌： Thermo
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已发表文章

免疫细胞化学 (ICC/IF)

Assay-dependent
-

流式细胞分析 (Flow)

5 µg
-
产品规格

种属反应

Human,Mouse,Rat

宿主/亚型

Rabbit / IgG

分类

Polyclonal

类型

Antibody

抗原

KKGWMDPQSKGIQTGRC, corresponding to amino acid residues 136-152 of mouse P2X7 receptor, Extracellular loop
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偶联物

FITC FITC FITC

激发/发射光谱

498/517 nm 查看光谱spectra

形式

Lyophilized

浓度

1 mg/mL

纯化类型

Antigen affinity chromatography

保存液

PBS, pH 7.4, with 1% BSA

内含物

0.05% sodium azide

保存条件

-20° C, Avoid Freeze/Thaw Cycles, store in dark

运输条件

Ambient (domestic); Wet ice (international)

产品详细信息

Reconstitution: 15 µL or 50 µL double distilled water (DDW), depending on the sample size. The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20C. The reconstituted solution can be stored at 4C, protected from the light, for up to 1 week. For longer periods, small aliquots should be stored at -20C. Avoid multiple freezing and thawing. Centrifuge all antibody preparations before use (10000 X g 5 min).

靶标信息

The product of this gene belongs to the family of purinoceptors for ATP. This receptor functions as a ligand-gated ion channel and is responsible for ATP-dependent lysis of macrophages through the formation of membrane pores permeable to large molecules. Activation of this nuclear receptor by ATP in the cytoplasm may be a mechanism by which cellular activity can be coupled to changes in gene expression. Multiple alternatively spliced variants have been identified, most of which fit nonsense-mediated decay criteria.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

生物信息学

蛋白别名: ATP receptor; MGC20089; P2X purinoceptor 7; p2X receptor 7; P2X7; P2X7 purinoceptor; P2X7 receptor; P2Z; P2Z receptor; Purinergic receptor; purinergic receptor P2X, ligand gated ion channel, 7; purinergic receptor P2X, ligand-gated ion channel, 7; purinergic receptor P2X7; purinergic receptor P2X7 variant A

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基因别名: AI467586; P2RX7; P2X(7); P2X7; P2X7R

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UniProt ID:(Human) Q99572, (Rat) Q64663, (Mouse) Q9Z1M0

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Entrez Gene ID:(Human) 5027, (Rat) 29665, (Mouse) 18439

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功能
lipopolysaccharide binding purinergic nucleotide receptor activity extracellular ATP-gated cation channel activity receptor binding protein binding ATP binding protein homodimerization activity magnesium ion binding receptor activity copper ion binding zinc ion binding channel activity protein serine/threonine kinase activator activity scaffold protein binding ion channel activity ligand-gated ion channel
参与通路
activation of MAPK activity cell morphogenesis phagolysosome assembly positive regulation of T cell mediated cytotoxicity regulation of sodium ion transport protein phosphorylation membrane protein ectodomain proteolysis phospholipid transfer to membrane membrane budding inflammatory response mitochondrion organization cell surface receptor signaling pathway blood coagulation response to mechanical stimulus response to zinc ion positive regulation of calcium ion transport into cytosol positive regulation of gene expression positive regulation of glutamate secretion positive regulation of gamma-aminobutyric acid secretion synaptic vesicle exocytosis protein processing phospholipid scrambling sensory perception of pain cytolysis positive regulation of bone mineralization cellular response to extracellular stimulus bleb assembly positive regulation of prostaglandin secretion response to lipopolysaccharide positive regulation of interleukin-6 production collagen metabolic process response to ATP response to fluid shear stress positive regulation of ion transmembrane transport purinergic nucleotide receptor signaling pathway T cell proliferation response to drug T cell homeostasis NAD transport negative regulation of MAPK cascade multicellular organismal protein catabolic process phospholipid translocation negative regulation of bone resorption negative regulation of cell volume positive regulation of glycolytic process positive regulation of cytolysis ceramide biosynthetic process pore complex assembly skeletal system morphogenesis homeostasis of number of cells within a tissue positive regulation of interleukin-1 alpha secretion positive regulation of interleukin-1 beta secretion defense response to Gram-positive bacterium release of sequestered calcium ion into cytosol protein oligomerization positive regulation of cytoskeleton organization response to calcium ion response to electrical stimulus regulation of killing of cells of other organism membrane depolarization positive regulation of mitochondrial depolarization positive regulation of lymphocyte apoptotic process cellular response to dsRNA reactive oxygen species metabolic process apoptotic signaling pathway extrinsic apoptotic signaling pathway positive regulation of bleb assembly positive regulation of protein phosphorylation cation transport calcium ion transport cell volume homeostasis plasma membrane organization response to bacterium response to organic substance gene expression programmed cell death response to organic cyclic compound organic cation transport neuronal action potential positive regulation of interleukin-1 beta production positive regulation of apoptotic process positive regulation of catalytic activity positive regulation of MAPK cascade positive regulation of ossification positive regulation of protein secretion positive regulation of cytokine secretion cellular response to organic cyclic compound cation transmembrane transport transport ion transport

参考图片

Cell surface detection of P2RX7 inlive intact human THP-1 monocytic leukemia cells: - (black line) cells. (red) Cells + rabbit IgG isotype control-FITC. (green) Cells + Anti-P2X7 Receptor (extracellular)-FITC Antibody (#APR-008-F), (5 µg).

Cell surface detection of P2RX7 in live intact mouse BV-2 microglia cells: - (black line) cells. (red) Cells + Rabbit IgG Isotype Control-FITC. (green) Cells + Anti-P2X7 Receptor (extracellular)-FITC Antibody (#APR-008-F), (5 µg).

Expression of P2RX7 in human K562 cells - Cell surface detection of P2RX7 in living K562 cells stained with Anti-P2X7 Receptor (extracellular)-FITC Antibody (#APR-008-F).

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货号：
APR-008-F-50UL-Thermo
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