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KCNMA1 (KCA1.1) (EXTRACELLULAR
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产品详细信息
Reconstitution: 25 µL, 50 µL or 0.2 mL double distilled water (DDW), depending on the sample size. The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20C. The reconstituted solution can be stored at 4C, protected from the light, for up to 1 week. For longer periods, small aliquots should be stored at -20C. Avoid multiple freezing and thawing. Centrifuge all antibody preparations before use (10000 X g 5 min).
靶标信息
Potassium channels are a group of ubiquitously expressed proteins that serve numerous functions in excitable and non-excitable cells. One class of integral membrane potassium channels is the large conductance, calcium-activated potassium channel (Maxi K+). Maxi K+ differs from most other potassium channels in that its activation is controlled by both increases in intracellular calcium and by membrane depolarization. Maxi K+ dual activation is possible because of its structure. The core of the channel, which is similar to other potassium channels, is a Maxi K+ alpha homotetramer that contains both a voltage sensor and an intracellular calcium binding domain. In vascular smooth muscle, an auxiliary beta-subunit is found in a 1:1 stoichiometry. The beta-subunit exhibits its effect on the Maxi K+ channel by effectively decreasing by 5- to 10- fold the concentration of calcium required to keep the pore open.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
生物信息学
蛋白别名: big potassium channel alpha subunit; BK channel; BK channel alpha subunit; BKCA alpha; BKCA alpha subunit; calcium-activated potassium channel alpha subunit; Calcium-activated potassium channel subunit alpha-1; Calcium-activated potassium channel, subfamily M subunit alpha-1; K(VCA)alpha; KCa1.1; Maxi K channel; maxi-K channel HSLO; MaxiK; mSlo1; potassium channel, calcium activated large conductance subfamily M alpha, member 1; potassium large conductance calcium-activated channel, subfamily M, alpha member 1; Slo homolog; Slo-alpha; Slo1; Slowpoke homolog; stretch-activated Kca channel
基因别名: 5730414M22Rik; bA205K10.1; BKCa; BKTM; hSlo; KCa1.1; KCNMA; KCNMA1; KCNMA1b; KCNMA1c; MaxiK; mSlo; mSLO1; SAKCA; SLO; SLO-ALPHA; SLO1
UniProt ID:(Human) Q12791, (Mouse) Q08460, (Rat) Q62976
Entrez Gene ID:(Human) 3778, (Mouse) 16531, (Rat) 83731
参考图片
Western blot analysis of rat (lanes 1 and 3) and mouse brain membranes (lanes 2 and 4): - 1,2. Anti-KCNMA1 (KCa1.1) (extracellular) Antibody (#APC-151), (1:200).3,4. Anti-KCNMA1 (KCa1.1) (extracellular) Antibody , preincubated with KCNMA1/KCa1.1 (extracellular) Blocking Peptide (#BLP-PC151).
Cell surface detection of KCa1.1 by indirect flow cytometry in live intact human THP-1 monocytic leukemia cells: - (black line) cells. (red) Cells + goat- Anti-rabbit-FITC. (green) Cells + Anti-KCNMA1 (KCa1.1) (extracellular) Antibody (#APC-151), (2.5μg) + goat- Anti-rabbit-FITC.