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NMDAR3A (GRIN3A) (EXTRACELLULA
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Reconstitution: 25 µL, 50 µL or 0.2 mL double distilled water (DDW), depending on the sample size. The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20C. The reconstituted solution can be stored at 4C for up to 1 week. For longer periods, small aliquots should be stored at -20C. Avoid multiple freezing and thawing. Centrifuge all antibody preparations before use (10000 x g 5 min).
靶标信息
Grin3a is an NMDA (N-methyl-D-aspartate) receptor subtype of glutamate-gated ion channels with reduced single-channel conductance, low calcium permeability and low voltage-dependent sensitivity to magnesium. Grin3a is mediated by glycine and may play a role in the development of dendritic spines. Further, Grin3a may play a role in PPP2CB-NMDAR mediated signaling mechanism. Grin3a belongs to the superfamily of glutamate-regulated ion channels, and function in physiological and pathological processes in the central nervous system. Grin3a shows greater than 90% identity to the corresponding subunit in rat. Studies in the knockout mouse deficient in Grin3a suggest that the protein may be involved in the development of synaptic elements by modulating NMDA receptor activity. Diseases associated with GRIN3A include Lingual-Facial-Buccal Dyskinesia.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
生物信息学
蛋白别名: GluN3A; glutamate receptor; Glutamate receptor chi-1; Glutamate receptor ionotropic, NMDA 3A; N-methyl-D-aspartate receptor; N-methyl-D-aspartate receptor subtype 3A; NMDAR-L; NMDAR-L1; NMDAR3A
基因别名: 6430537F04; A830097C19Rik; chi-1; GluN3A; Grin3a; Kiaa1973; mKIAA1973; NMDAR-L; NR3; NR3A
UniProt ID:(Rat) Q9R1M7, (Mouse) A2AIR5
Entrez Gene ID:(Rat) 191573, (Mouse) 242443
参考图片
Western blot analysis of rat (lanes 1 and 3) and mouse (lanes 2 and 4) brain membranes: - 1,2. Anti-NMDAR3A (GRIN3A) (extracellular) Antibody (#AGC-030), (1:200).3,4. Anti-NMDAR3A (GRIN3A) (extracellular) Antibody , preincubated with NMDAR3A/GRIN3A (extracellular) Blocking Peptide (#BLP-GC030).