全部商品分类
SLO BETA 1 (KCNMB1) ANTIBODY
下载产品说明书 下载SDS
用小程序，查商品更便捷
收藏
对比
咨询种属反应
宿主/亚型
分类
类型
抗原
偶联物
形式
浓度
纯化类型
保存液
内含物
保存条件
运输条件
产品详细信息
Reconstitution: 25 µL, 50 µL or 0.2 mL double distilled water (DDW), depending on the sample size. The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20C. The reconstituted solution can be stored at 4C for up to 1 week. For longer periods, small aliquots should be stored at -20C. Avoid multiple freezing and thawing. Centrifuge all antibody preparations before use (10000 x g 5 min).
靶标信息
Potassium channels are a group of ubiquitously expressed proteins that serve numerous functions in excitable and non-excitable cells. One class of integral membrane potassium channels is the large conductance, calcium-activated potassium channel (Maxi K+). Maxi K+ differs from most other potassium channels in that its activation is controlled by both increases in intracellular calcium and by membrane depolarization. Maxi K+ dual activation is possible because of its structure. The core of the channel, which is similar to other potassium channels, is a Maxi K+ alpha homotetramer that contains both a voltage sensor and an intracellular calcium binding domain. In vascular smooth muscle, an auxiliary beta-subunit is found in a 1:1 stoichiometry. The beta-subunit exhibits its effect on the Maxi K+ channel by effectively decreasing by 5- to 10- fold the concentration of calcium required to keep the pore open. Maxi K+ beta is the target for possible therapeutics because of its role in blood flow and blood pressure regulation.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
生物信息学
蛋白别名: big potassium channel beta subunit 1; BK channel beta subunit; BK channel beta subunit 1; BK channel subunit beta-1; BKbeta; calcium-activated potassium channel beta subunit; Calcium-activated potassium channel subunit beta; Calcium-activated potassium channel subunit beta-1; Calcium-activated potassium channel, subfamily M subunit beta-1; Charybdotoxin receptor subunit beta-1; K(VCA)beta-1; large conductance Ca2+-activated K+ channel beta 1 subunit; Maxi K channel subunit beta-1; MaxiK channel beta-subunit 1; potassium channel subfamily M regulatory beta subunit 1; potassium large conductance calcium-activated channel, subfamily M, beta member 1; Slo-beta; Slo-beta-1; Slowpoke-beta
基因别名: BKbeta; BKbeta1; hbeta1; hslo-beta; K(VCA)beta; k(VCA)beta-1; KCNMB1; SLO-BETA; slo-beta-1
UniProt ID:(Human) Q16558, (Rat) P97678, (Mouse) Q8CAE3
Entrez Gene ID:(Human) 3779, (Rat) 29747, (Mouse) 16533
参考图片
Western blot analysisof rat smooth muscle lysate: - 1. Anti-slo beta 1 (KCNMB1) Antibody (#APC-036), (1:200). 2. Anti-slo beta 1 (KCNMB1) Antibody , preincubated with slo beta 1/KCNMB1 Blocking Peptide (#BLP-PC036).
Western blot analysisof rat colon lysate: - 1. Anti-slo beta 1 (KCNMB1) Antibody (#APC-036), (1:400). 2. Anti-slo beta 1 (KCNMB1) Antibody , preincubated with slo beta 1/KCNMB1 Blocking Peptide (#BLP-PC036).