全部商品分类
下载产品说明书 下载SDS
用小程序，查商品更便捷
收藏
对比
咨询种属反应
宿主/亚型
分类
类型
抗原
偶联物
形式
浓度
纯化类型
保存液
内含物
保存条件
运输条件
产品详细信息
Reconstitution: 25 µL, 50 µL or 0.2 mL double distilled water (DDW), depending on the sample size. The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20C. The reconstituted solution can be stored at 4C for up to 1 week. For longer periods, small aliquots should be stored at -20C. Avoid multiple freezing and thawing. Centrifuge all antibody preparations before use (10000 x g 5 min).
靶标信息
TRPV1 (Transient Receptor Potential Cation Channel Subfamily V Member 1) is a receptor for capsaicin, the main pungent ingredient in hot chili peppers, and elicits a sensation of burning pain by selectively activating sensory neurons. TRPV1 is a non-selective cation channel that is structurally related to members of the TRP family of ion channels such as TRPC3 and TRPC6. TRPV1 is permeable to calcium, magnesium, and monovalent cations of sodium and potassium. Structurally, TRPV1 contains 6 trans-membrane domains, a P-loop membrane domain and 3 ankyrin repeat domains. TRPV1 is also activated by increases in temperature in the noxious range, suggesting that it functions as a transducer of painful thermal stimuli in vivo. TRPV1 seems to mediate proton influx and may be involved in intracellular acidosis in nociceptive neurons. The expression of TRPV1 appears to be limited to neurons within the sensory ganglia. Four transcript variants encoding TRPV1 with variations in th 5' UTR sequence have been described. Diseases associated with TRPV1 include Irritable Bowel Syndrome (IBS) and Bladder Disease.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
生物信息学
蛋白别名: Capsaicin receptor; DKFZp434K0220; Osm-9-like TRP channel 1; OTRPC1; Transient receptor potential cation channel subfamily V member 1; transient receptor potential vanilloid 1 supraoptic nucleus; TrpV1; Vanilloid receptor; Vanilloid receptor 1; vanilloid receptor subtype 1; vanilloid receptor type 1 like protein 1; Vanilloid receptor type 1-like; vanilloid type 1 receptor
基因别名: Trpv1; TRPV1_SON; VR.5'sv; Vr1; Vr1l; Vr1l1
UniProt ID:(Rat) O35433
Entrez Gene ID:(Rat) 83810
参考图片
Expression of TRPV1 in rat DRGs - Immunohistochemical staining of TRPV1 in rat dorsal root ganglion (DRG) using Guinea pig Anti-TRPV1 (VR1) Antibody (#ACC-030-GP), (1:200). A. TRPV1 staining (red) appears in some DRG cells (arrows). B. DAPI counterstain (blue) is used to stain nuclei. C. Merged image of panels A and B.
Western blot analysis of Rat DRG lysate: - 1. Guinea pig Anti-TRPV1 (VR1) Antibody (#ACC-030-GP), (1:200). 2. Guinea pig Anti-TRPV1 (VR1) Antibody preincubated with TRPV1/VR1 Blocking Peptide (#BLP-CC030).Following a broad screen of secondary antibodies, the following were used for these applications: Western blot analysis: #106-035-006 (Jackson Immunodetect).