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产品详细信息
Reconstitution: 25 µL, 50 µL or 0.2 mL double distilled water (DDW), depending on the sample size. The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20C. The reconstituted solution can be stored at 4C for up to 1 week. For longer periods, small aliquots should be stored at -20C. Avoid multiple freezing and thawing. Centrifuge all antibody preparations before use (10000 x g 5 min).
靶标信息
Glutamate receptors mediate most excitatory neurotransmission in the brain and play an important role in neural plasticity, neural development and neurodegeneration. Ionotropic glutamate receptors are categorized into NMDA receptors and kainate/AMPA receptors, both of which contain glutamate-gated, cation-specific ion channels. Kainate/AMPA receptors are co-localized with NMDA receptors in many synapses and consist of seven structurally related subunits designated GluR-1 to -7. The kainate/AMPA receptors are primarily responsible for the fast excitatory neuro-transmission by glutamate, whereas the NMDA receptors exhibit slow kinetsis of Ca2+ ions and a high permeability for Ca2+ ions. The NMDA receptors consist of five subunits: epsilon 1, 2, 3, 4 and one zeta subunit. The zeta subunit is expressed throughout the brainstem whereas the four epsilon subunits display limited distribution.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
生物信息学
蛋白别名: EB11; estrogen receptor binding CpG island; GluN2D; glur epsilon 4; GluRepsilon4; Glutamate [NMDA] receptor subunit epsilon-4; glutamate receptor; Glutamate receptor ionotropic, NMDA 2D; glutamate receptor, ionotropic, N-methyl D-aspartate 2D; glutamate receptor, ionotropic, NMDA2D; ionotropic NMDA glutamate receptor epsilon 4 subunit type 2; N-methyl D-aspartate receptor subtype 2D; N-methyl-d-aspartate receptor subunit 2D; NMDAR2D; NR2D
基因别名: EB11; GluN2D; GRIN2D; NMDAR2D; NR2D
UniProt ID:(Human) O15399, (Mouse) Q03391, (Rat) Q63381
Entrez Gene ID:(Human) 2906, (Mouse) 14814, (Rat) 24412
参考图片
Expression of NMDA receptor 2D in rat reticular thalamic nucleus - Immunohistochemical staining of immersion-fixed, free floating rat brain frozen sections using Anti-NMDAR2D (GRIN2D) (extracellular) Antibody (#AGC-020), (1:200). A. Staining (green) appears in a discreet population of cells (thin arrows). B. The same section was stained for parvalbumin (red) and cell nuclei were visualized with DAPI (blue). Cells positive for NR2D but negative for parvalbumin (thick arrow, shown in A) and cells positive for both NR2D and parvalbumin (vertical arrow) are both present.
Western blot analysis of mouse (lanes 1 and 3) and rat (lanes 2 and 4) brain membranes: - 1,2. Anti-NMDAR2D (GRIN2D) (extracellular) Antibody (#AGC-020), (1:200).3,4. Anti-NMDAR2D (GRIN2D) (extracellular) Antibody , preincubated with NMDAR2D/GRIN2D (extracellular) Blocking Peptide (#BLP-GC020).