NMDAR1 (GLUN1) (EXTRACELLULAR)

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NMDAR1 (GLUN1) (EXTRACELLULAR)

品牌： Thermo

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产品介绍

产品信息

应用

建议稀释比

已发表文章

免疫印迹 (WB)

1:200

免疫组化（冰冻） (IHC (F))

1:400

产品规格

种属反应

Human,Mouse,Rat

宿主/亚型

Guinea pig / IgG

分类

Polyclonal

类型

Antibody

抗原

ETEKPRGYQMSTRLK(C), corresponding to amino acid residues 385-399 of rat GluN1, Extracellular, N-terminus

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偶联物

Unconjugated Unconjugated Unconjugated

形式

Lyophilized

浓度

0.8 mg/mL

纯化类型

Antigen affinity chromatography

保存液

PBS, pH 7.4, with 1% BSA

内含物

0.05% sodium azide

保存条件

-20° C, Avoid Freeze/Thaw Cycles

运输条件

Ambient (domestic); Wet ice (international)

产品详细信息

Reconstitution: 25 µL, 50 µL or 0.2 mL double distilled water (DDW), depending on the sample size. The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20C. The reconstituted solution can be stored at 4C for up to 1 week. For longer periods, small aliquots should be stored at -20C. Avoid multiple freezing and thawing. Centrifuge all antibody preparations before use (10000 x g 5 min).

靶标信息

NMDAR1 encodes a protein that is a critical subunit of N-methyl-D-aspartate receptors, members of the glutamate receptor channel superfamily which are heteromeric protein complexes with multiple subunits arranged to form a ligand-gated ion channel. These subunits play a key role in the plasticity of synapses, which is believed to underlie memory and learning. Cell-specific factors are thought to control expression of different isoforms, possibly contributing to the functional diversity of the subunits. Alternatively spliced transcript variants have been described.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

生物信息学

蛋白别名: GluN1; Glun1r; glutamate [NMDA] receptor subunit zeta 1; Glutamate [NMDA] receptor subunit zeta-1; glutamate receptor; Glutamate receptor ionotropic, NMDA 1; glutamate receptor, ionotropic, N-methyl D-aspartate 1; N-methyl-D-aspartate glutamate receptor; N-methyl-D-aspartate receptor channel, subunit zeta-1; N-methyl-D-aspartate receptor subunit NR1; neurotransmitter receptor; NMD-R1; NMDA R1 receptor C1 cassette; NMDA receptor 1; NMDZ1; NMZ1; NR1C1; NR1C2; NR1C2'; NR1N1; pGluN1; RP11-350O14.1

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基因别名: GluN1; GluRdelta1; Glurz1; GluRzeta1; GRIN1; M100174; MRD8; NMD-R1; NMDA1; Nmdar; NMDAR1; NR1; Rgsc174

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UniProt ID:(Human) Q05586, (Rat) P35439, (Mouse) P35438

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Entrez Gene ID:(Human) 2902, (Rat) 24408, (Mouse) 14810

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参与通路

MAPK cascade conditioned taste aversion suckling behavior response to amphetamine cation transport cellular calcium ion homeostasis chemical synaptic transmission respiratory gaseous exchange long-term memory adult locomotory behavior olfactory learning visual learning propylene metabolic process sensory perception of pain pons maturation cerebral cortex development regulation of ion transmembrane transport social behavior ionotropic glutamate receptor signaling pathway synaptic transmission, glutamatergic regulation of membrane potential positive regulation of apoptotic process response to morphine negative regulation of neuron apoptotic process positive regulation of GTPase activity regulation of respiratory gaseous exchange response to ethanol positive regulation of transcription from RNA polymerase II promoter ephrin receptor signaling pathway regulation of long-term neuronal synaptic plasticity rhythmic process regulation of dendrite morphogenesis regulation of axonogenesis protein tetramerization response to calcium ion regulation of synapse assembly calcium ion homeostasis excitatory postsynaptic potential prepulse inhibition male mating behavior response to fungicide calcium ion transmembrane transport cellular response to manganese ion positive regulation of excitatory postsynaptic potential startle response calcium ion transport learning or memory learning memory associative learning regulation of cell communication positive regulation of cell death response to organic cyclic compound response to amine ion transmembrane transport regulation of neuron apoptotic process regulation of synaptic plasticity regulation of neuronal synaptic plasticity neuromuscular process transport ion transport cation transmembrane transport

参考图片

Multiplex staining of NMDAR1 and ASCT1 in mouse hippocampus - Immunohistochemical staining of immersion-fixed, free floating rat brain frozen sections using Guinea pig Anti-NMDAR1 (GluN1) (extracellular) Antibody (#AGC-001-GP), (1:600) and rabbit Anti-ASCT1 (SLC1A4) Antibody (#ANT-081), (1:300). A. NMDAR1 (in red) appears in profiles of hippocampal dentate gyrus interneurons (arrows). B. ASCT1 (in green) appears in the extracellular matrix of the subgranular layer (SGL). C. Merge of the two images demonstrates adjacent localization in several neurons (arrows). Cell nuclei are stained with DAPI (blue). GL = granule layer.

Multiplex staining of NMDAR1 and M4 muscarinic acetylcholine receptor in mouse parietal cortex - Immunohistochemical staining of immersion-fixed, free floating mouse brain frozen sections using rabbit Anti-CHRM4 Antibody (#AMR-004), (1:400) and Guinea pig Anti-NMDAR1 (GluN1) (extracellular) Antibody (#AGC-001-GP), (1:1200). A. M4 muscarinic receptor staining (green). B. NMDAR1 staining (red) in same section. C. Merge of the two images reveals several cells expressing both M4 muscarinic receptor and NMDAR1 (arrows). Cell nuclei were stained with DAPI (blue).

Western blot analysis of rat brain lysate (lanes 1 and 3) and mouse brain lysate (lanes 2 and 4): - 1. 2. Guinea pig Anti-NMDAR1 (GluN1) (extracellular) Antibody (#AGC-001-GP), (1:200).3.4. Guinea pig Anti-NMDAR1 (GluN1) (extracellular) Antibody , preincubated with NMDAR1/GluN1 (extracellular) Blocking Peptide (#BLP-GC001).

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货号：

AGC-001-GP200UL

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询价

200UL

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