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Mouse Anti-Human TCR α/β Antibody (S-R686)

Mouse Anti-Human TCR α/β Antibody (S-R686)

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反应种属:
Hu
来源宿主:
Mouse
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产品介绍
产品介绍
产品信息
荧光素标记
Unconjugated
抗原名称
TCR α/β
宿主
Mouse
同种型
IgM,k
克隆号
S-R686
浓度
2 mg/ml
性状
Liquid
缓冲体系

PBS pH7.4

产品类型
Mouse mAb
应用
实验应用
FCM
反应种属
Hu
稀释度
  • ELISA

  • Sandwich ELISA

  • CLIA

  • Lateral Flow

  • Dot Blot

  • WB

  • IP

  • IHC-P

  • ICC

  • IF

  • ICFCM

  • FCM

    1:200
  • mIHC

  • ChIP

背景
别名
α/β TCR; TCR α/β
背景

The T cell receptor (TCR) α and β proteins are essential components of the αβ T cell receptor, a heterodimeric surface protein expressed on T lymphocytes that recognizes antigenic peptides presented by major histocompatibility complex (MHC) molecules. The TCR α chain is encoded by the TRAC (T cell receptor alpha constant) and TRAV (T cell receptor alpha variable) genes, while the TCR β chain is encoded by the TRBC (T cell receptor beta constant) and TRBV (T cell receptor beta variable) genes, along with diversity (TRBD) and joining (TRBJ) segments, enabling extensive combinatorial diversity. Structurally, both chains consist of a variable (V) domain responsible for antigen recognition and a constant (C) domain that anchors the receptor to the cell membrane. The TCR αβ heterodimer associates with the CD3 complex (CD3γε, CD3δε, and CD247 ζζ) to form a functional TCR-CD3 signaling unit, which transmits activation signals upon peptide-MHC engagement. TCR β undergoes V(D)J recombination during thymic development, contributing to the receptor's antigen specificity, whereas TCR α lacks a D segment but still undergoes recombination for diversity. Mutations or dysregulation in TCR α/β genes can lead to immune disorders, including T cell malignancies and autoimmune diseases. TCR αβ T cells are critical for adaptive immunity, mediating responses against infections, tumors, and self-antigens in autoimmune conditions.

细胞定位
Cell membrane
制备和贮存
保存方式

12 months from date of receipt / reconstitution, 2 to 8 °C as supplied.

数据库链接
Accession
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货号:
S0B5513-25μl
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