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产品信息
商品描述
ZNL 02-096 is a rapid and selective degrader of Wee1 (IC50=3.58 nM).ZNL 02-096 selectively degrades Wee1 at submolar concentrations without damaging PLK1, a secondary target of AZD 1775.ZNL 02-096 induces degradation of Wee1 and accumulation of DNA damage in MOLT-4 cells in vitro, In vitro in MOLT-4 cells, ZNL 02-096 induced Wee1 degradation, accumulation of DNA damage, cell cycle arrest in G2/M phase and apoptosis.ZNL 02-096 showed anti-proliferative effects in 300 cancer cell lines.
分子量
799.88
纯度
≥98%
可溶性
DMSO : 7.5 mg/mL (20.64 mM)
外观
Pink to red Solid
In vitro(体外研究)
ZNL 02-096 (1 nM-10 μM; 24, 48, and 72 h; OVCAR8, COV362, and Kuramochi cells) induces CRBN-dependent anti-proliferative effects and synergizes with Olaparib. ZNL 02-096 (6 h) degrades Wee1 in OVCAR8 cells, with maximal degradation observed at a 100 nM treatment.[1] ZNL 02-096 (100 nM; 24 h) induces DNA damage, apoptosis, and deregulation of the G2/M checkpoint.[1]
背景
分子式
C42H45N11O6
CAS号
2414418-49-6
制备和贮存
保存方式
Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution.
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