Histone H3K27M Rabbit Monoclonal Antibody - Biotinylated (Clone RM192)

Rabbit

A peptide corresponding to histone H3K27M

Histone 3 is a nuclear protein and a component of the nucleosome core, a basic unit of chromatin, that is essential for organizing genomic DNA in eukaryotic nuclei.1 It is a globular protein that contains a histone fold domain with a C-terminal α-helix that facilitates nucleosome interactions and chromatin compaction, as well as an unstructured N-terminal tail that extends outside of the nucleosome core, both of which are subject to various post-translational modifications (PTMs), including ubiquitination, acetylation, methylation, and phosphorylation.1,2,3 Histone H3 has a key role in transcriptional regulation.4 Expression of histone H3 containing a lysine-to-methionine substitution at residue 27 (H3K27M) is associated with tumor progression in pediatric midline gliomas.{Filbin2018} Cayman's Histone H3K27M Rabbit Monoclonal Antibody - Biotinylated (Clone RM192) can be used for ELISA, immunohistochemistry (IHC), and Western blot (WB) applications.WARNING This product is not for human or veterinary use.

For immunochemical detection of histone H3K27M

IgG

RM192

Antibodies/Primary Antibodies/Conjugated Antibodies/Monoclonal Antibodies

ELISA,Immunohistochemistry,Western Blot

(+) Histone H3K27M (-) Histone H3

≥ 1 year