3‘-羟基楝酰胺

Rocaglamide C is a derivative of Rocaglamide with similar properties. The compound has been observed to have an apoptotic effect on leukemic cells through the mitochondrial pathway. Through differential regulation of FLIP_S/L (c-FLIP) and FAS-L expression the compound has been documented to promote activation induced cell death in leukemic T cells through the JNK activation as well as inhibition of NF-κB activation in non-leukemic T cells. Rocaglamide C also retains insecticide activity towards the larvae Spodoptera littoralis (0.8 to 80 ppm).

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