R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.

Toll/Interleukin-1 Receptor Domain Derived from TcpC (TIR-TcpC) Ameliorates Experimental Autoimmune Arthritis by Down-modulating Th17 Cell Response
Authors: Shweta Pasi
J Biol Chem, 2016;291(23):12358-69.
Species: Mouse
Sample Type: Whole Cells
Application: Bioassay
Enhanced immunoregulation of mesenchymal stem cells by IL-10-producing type 1 regulatory T cells in collagen-induced arthritis
Authors: Jung-Yeon Lim
Sci Rep, 2016;6(0):26851.
Species: Mouse
Sample Type: Cell Culture Supernates
Application: Bioassay
Murine iPSC-Derived Macrophages as a Tool for Disease Modeling of Hereditary Pulmonary Alveolar Proteinosis due to Csf2rb Deficiency
Stem Cell Reports, 2016;0(0):.
Species: Mouse
Sample Type: Whole Cells
Application: Bioassay
RGS10 deficiency ameliorates the severity of disease in experimental autoimmune encephalomyelitis.
Authors: Lee J, Kannarkat G, Chung J, Joon Lee H, Graham K, Tansey M
J Neuroinflammation, 2016;13(1):24.
Species: Mouse
Sample Type: Whole Cells
Application: Bioassay
p(70S6K1) in the TORC1 pathway is essential for the differentiation of Th17 Cells, but not Th1, Th2, or Treg cells in mice.
Authors: Sasaki C, Chen G, Munk R, Eitan E, Martindale J, Longo D, Ghosh P
Eur J Immunol, 2016;46(1):212-22.
Species: Mouse
Sample Type: Whole Cells
Application: Bioassay
T cells are necessary for ILC2 activation in house dust mite-induced allergic airway inflammation in mice
Authors: BW Li, MJ de Bruijn, I Tindemans, M Lukkes, A KleinJan, HC Hoogsteden, RW Hendriks
Eur J Immunol, 2016;0(0):.
Species: Mouse
Sample Type: Whole Cells
Application: Bioassay
Leptin directly promotes T-cell glycolytic metabolism to drive effector T-cell differentiation in a mouse model of autoimmunity
Eur J Immunol, 2016;0(0):.
Species: Mouse
Sample Type: Whole Cells
Application: Bioassay
Phenotypic and Functional Plasticity of Murine Intestinal NKp46+ Group 3 Innate Lymphoid Cells
J Immunol, 2016;196(11):4731-8.
Species: Mouse
Sample Type: Whole Cells
Application: Bioassay
Alternative splicing of MALT1 controls signalling and activation of CD4(+) T cells
Authors: I Meininger, RA Griesbach, D Hu, T Gehring, T Seeholzer, A Bertossi, J Kranich, A Oeckinghau, AC Eitelhuber, U Greczmiel, A Gewies, M Schmidt-Su, J Ruland, T Brocker, V Heissmeyer, F Heyd, D Krappmann
Nat Commun, 2016;7(0):11292.
Species: Mouse
Sample Type: Whole Cells
Application: Bioassay
Negative regulation of the hepatic fibrogenic response by suppressor of cytokine signaling 1
Cytokine, 2016;82(0):58-69.
Species: Mouse
Sample Type: Whole Cells
Application: Bioassay
Renalase expression by melanoma and tumor associated-macrophages promotes tumor growth through a STAT3-mediated mechanism
Cancer Res, 2016;0(0):.
Species: Mouse
Sample Type: Whole Cells
Application: Bioassay
IL-1 signaling modulates activation of STAT transcription factors to antagonize retinoic acid signaling and control the TH17 cell-iTreg cell balance.
Authors: Basu R, Whitley S, Bhaumik S, Zindl C, Schoeb T, Benveniste E, Pear W, Hatton R, Weaver C
Nat Immunol, 2015;16(3):286-95.
Species: Mouse
Sample Type: Whole Cells
Application: Bioassay
Mouse Resistin (mRetn): cloning, expression and purification in Escherichia coli and the potential regulative effects on murine bone marrow hematopoiesis.
Authors: Wang F, Gao J, Malisani A, Xi X, Han W, Wan X
BMC Biotechnol, 2015;15(0):105.
Species: Mouse
Sample Type: Whole Cells
Application: Bioassay
ShcA regulates late stages of T cell development and peripheral CD4+ T cell numbers.
Authors: Buckley M, Trampont P, Arandjelovic S, Fond A, Juncadella I, Ravichandran K
J Immunol, 2015;194(4):1665-76.
Species: Mouse
Sample Type: Whole Cells
Application: Bioassay
CXCL13 antibody for the treatment of autoimmune disorders.
Authors: Klimatcheva E, Pandina T, Reilly C, Torno S, Bussler H, Scrivens M, Jonason A, Mallow C, Doherty M, Paris M, Smith E, Zauderer M
BMC Immunol, 2015;16(0):6.
Species: Mouse
Sample Type: Whole Cells
Application: Bioassay
Grb10 is involved in BCR-ABL-positive leukemia in mice.
Authors: Illert, A L, Albers, C, Kreutmair, S, Leischner, H, Peschel, C, Miething, C, Duyster, J
Leukemia, 2015;29(4):858-68.
Species: Mouse
Sample Type: Whole Tissue
Application: Bioassay
Deubiquitinase DUBA is a post-translational brake on interleukin-17 production in T cells.
Authors: Rutz S, Kayagaki N, Phung Q, Eidenschenk C, Noubade R, Wang X, Lesch J, Lu R, Newton K, Huang O, Cochran A, Vasser M, Fauber B, DeVoss J, Webster J, Diehl L, Modrusan Z, Kirkpatrick D, Lill J, Ouyang W, Dixit V
Nature, 2015;518(7539):417-21.
Species: Mouse
Sample Type: Whole Cells
Application: Bioassay
Immune requirements for protective Th17 recall responses to Mycobacterium tuberculosis challenge.
Authors: Monin L, Griffiths K, Slight S, Lin Y, Rangel-Moreno J, Khader S
Mucosal Immunol, 2015;8(5):1099-109.
Species: Mouse
Sample Type: Whole Cells
Application: Bioassay
Interleukin-6 Stimulates Defective Angiogenesis.
Authors: Gopinathan G, Milagre C, Pearce O, Reynolds L, Hodivala-Dilke K, Leinster D, Zhong H, Hollingsworth R, Thompson R, Whiteford J, Balkwill F
Cancer Res, 2015;75(15):3098-107.
Species: Mouse
Sample Type: Whole Tissue
Application: Bioassay
Identification of Tetraazacyclic Compounds as Novel Potent Inhibitors Antagonizing RORgammat Activity and Suppressing Th17 Cell Differentiation.
Authors: Ding Q, Zhao M, Yu B, Bai C, Huang Z
PLoS ONE, 2015;10(9):e0137711.
Species: Mouse
Sample Type: Whole Cells
Application: Bioassay
KIM-1-mediated phagocytosis reduces acute injury to the kidney.
Authors: Yang L, Brooks C, Xiao S, Sabbisetti V, Yeung M, Hsiao L, Ichimura T, Kuchroo V, Bonventre J
J Clin Invest, 2015;125(4):1620-36.
Species: Mouse
Sample Type: Cell Lysates
Application: ELISA Standard
IkappaBNS regulates murine Th17 differentiation during gut inflammation and infection.
Authors: Annemann M, Wang Z, Plaza-Sirvent C, Glauben R, Schuster M, Ewald Sander F, Mamareli P, Kuhl A, Siegmund B, Lochner M, Schmitz I
J Immunol, 2015;194(6):2888-98.
Species: Mouse
Sample Type: Whole Cells
Application: Bioassay
Coexistent ARID1A-PIK3CA mutations promote ovarian clear-cell tumorigenesis through pro-tumorigenic inflammatory cytokine signalling.
Authors: Chandler, Ronald L, Damrauer, Jeffrey, Raab, Jesse R, Schisler, Jonathan, Wilkerson, Matthew, Didion, John P, Starmer, Joshua, Serber, Daniel, Yee, Della, Xiong, Jessie, Darr, David B, Pardo-Manuel de Villena, Fernando, Kim, William, Magnuson, Terry
Nat Commun, 2015;6(0):6118.
Species: Mouse
Sample Type: Whole Cells
Application: Bioassay
A Key Role for Leukemia Inhibitory Factor in C26 Cancer Cachexia.
Authors: Seto D, Kandarian S, Jackman R
J Biol Chem, 2015;290(32):19976-86.
Species: Mouse
Sample Type: Whole Cells
Application: Bioassay
ROR inverse agonist suppresses insulitis and prevents hyperglycemia in a mouse model of type 1 diabetes.
Authors: Solt L, Banerjee S, Campbell S, Kamenecka T, Burris T
Endocrinology, 2015;156(3):869-81.
Species: Mouse
Sample Type: Whole Cells
Application: Bioassay
Autocrine amplification of immature myeloid cells by IL-6 in multiple myeloma-infiltrated bone marrow.
Authors: Matthes T, Manfroi B, Zeller A, Dunand-Sauthier I, Bogen B, Huard B
Leukemia, 2015;29(9):1882-90.
Species: Mouse
Sample Type: Whole Cells
Application: Bioassay
Netrin-1 promotes adipose tissue macrophage retention and insulin resistance in obesity.
Authors: Ramkhelawon B, Hennessy E, Menager M, Ray T, Sheedy F, Hutchison S, Wanschel A, Oldebeken S, Geoffrion M, Spiro W, Miller G, McPherson R, Rayner K, Moore K
Nat Med, 2014;20(4):377-84.
Species: Mouse
Sample Type: Whole Cells
Application: Bioassay
Attenuation of experimental colitis in glutathione peroxidase 1 and catalase double knockout mice through enhancing regulatory T cell function.
Authors: Kim H, Lee A, Choi E, Kie J, Lim W, Lee H, Moon B, Seoh J
PLoS ONE, 2014;9(4):e95332.
Species: Mouse
Sample Type: Whole Cells
Application: Bioassay
M2 kupffer cells promote hepatocyte senescence: an IL-6-dependent protective mechanism against alcoholic liver disease.
Authors: Wan J, Benkdane M, Alons E, Lotersztajn S, Pavoine C
Am J Pathol, 2014;184(6):1763-72.
Species: Mouse
Sample Type: Whole Cells
Application: Bioassay
IL-21 induces IL-22 production in CD4+ T cells.
Authors: Yeste A, Mascanfroni I, Nadeau M, Burns E, Tukpah A, Santiago A, Wu C, Patel B, Kumar D, Quintana F
Nat Commun, 2014;5(0):3753.
Species: Mouse
Sample Type: Whole Cells
Application: Bioassay
Gene therapy delivery of myelin oligodendrocyte glycoprotein (MOG) via hematopoietic stem cell transfer induces MOG-specific B cell deletion.
Authors: Chung, Jie-Yu, Figgett, William, Fairfax, Kirsten, Bernard, Claude, Chan, James, Toh, Ban-Hock, Mackay, Fabienne, Alderuccio, Frank
J Immunol, 2014;192(6):2593-601.
Species: Mouse
Sample Type: Whole Cells
Application: Bioassay
Role of IL-6 in exercise training- and cold-induced UCP1 expression in subcutaneous white adipose tissue.
Authors: Knudsen J, Murholm M, Carey A, Bienso R, Basse A, Allen T, Hidalgo J, Kingwell B, Febbraio M, Hansen J, Pilegaard H
PLoS ONE, 2014;9(1):e84910.
Species: Mouse
Sample Type: In Vivo
Application: InVivo
Altered inactivation of commensal LPS due to acyloxyacyl hydrolase deficiency in colonic dendritic cells impairs mucosal Th17 immunity.
Authors: Janelsins, Brian M, Lu, Mingfang, Datta, Sandip K
Proc Natl Acad Sci U S A, 2014;111(1):373-8.
Species: Mouse
Sample Type: Whole Cells
Application: Bioassay
PERK-dependent activation of JAK1 and STAT3 contributes to endoplasmic reticulum stress-induced inflammation.
Authors: Meares G, Liu Y, Rajbhandari R, Qin H, Nozell S, Mobley J, Corbett J, Benveniste E
Mol Cell Biol, 2014;34(20):3911-25.
Species: Mouse
Sample Type: Whole Cells
Application: Bioassay
TGF-beta signaling initiated in dendritic cells instructs suppressive effects on Th17 differentiation at the site of neuroinflammation.
Authors: Speck S, Lim J, Shelake S, Matka M, Stoddard J, Farr A, Kuchroo V, Laouar Y
PLoS ONE, 2014;9(7):e102390.
Species: Mouse
Sample Type: Cell culture supernatant
Application: ELISA Standard
Suppression of Th1-mediated autoimmunity by embryonic stem cell-derived dendritic cells.
Authors: Ikeda T, Hirata S, Takamatsu K, Haruta M, Tsukamoto H, Ito T, Uchino M, Ando Y, Nagafuchi S, Nishimura Y, Senju S
PLoS ONE, 2014;9(12):e115198.
Species: Mouse
Sample Type: Whole Cells
Application: Bioassay
The DNA binding property of PML/RARA but not the integrity of PML nuclear bodies is indispensable for leukemic transformation.
Authors: Liu X, Yuan H, Peres L, Chen S, Chen Z, de The H, Zhou J, Zhu J
PLoS ONE, 2014;9(8):e104906.
Species: Mouse
Sample Type: Whole Cells
Application: Bioassay
Innate Stat3-mediated induction of the antimicrobial protein Reg3gamma is required for host defense against MRSA pneumonia.
Authors: Choi S, McAleer J, Zheng M, Pociask D, Kaplan M, Qin S, Reinhart T, Kolls J
J Exp Med, 2013;210(3):551-61.
Species: Mouse
Sample Type: Whole Cells
Application: Bioassay
Exposure to atmospheric particulate matter enhances Th17 polarization through the aryl hydrocarbon receptor.
Authors: van Voorhis, Michael, Knopp, Samantha, Julliard, Walker, Fechner, John H, Zhang, Xiaoji, Schauer, James J, Mezrich, Joshua D
PLoS ONE, 2013;8(12):e82545.
Species: Mouse
Sample Type: whole cells
Application: cell culture
Kynurenine 3-monooxygenase mediates inhibition of Th17 differentiation via catabolism of endogenous aryl hydrocarbon receptor ligands.
Authors: Stephens G, Wang Q, Swerdlow B, Bhat G, Kolbeck R, Fung M
Eur J Immunol, 2013;43(7):1727-34.
Species: Mouse
Sample Type: whole cells
Application: cell culture
IL-27 acts on DCs to suppress the T cell response and autoimmunity by inducing expression of the immunoregulatory molecule CD39.
Authors: Mascanfroni, Ivan D, Yeste, Ada, Vieira, Silvio M, Burns, Evan J, Patel, Bonny, Sloma, Ido, Wu, Yan, Mayo, Lior, Ben-Hamo, Rotem, Efroni, Sol, Kuchroo, Vijay K, Robson, Simon C, Quintana, Francisc
Nat Immunol, 2013;14(10):1054-63.
Species: Mouse
Sample Type: whole cells
Application: Bioassay
p53 controls autoimmune arthritis via STAT-mediated regulation of the Th17 cell/Treg cell balance in mice.
Authors: Park J, Lim M, Cho M, Ryu J, Moon Y, Jhun J, Byun J, Kim E, Hwang S, Ju J, Kwok S, Kim H
Arthritis Rheum, 2013;65(4):949-59.
Species: Mouse
Sample Type: Whole Cells
Application: Bioassay
Acteoside suppresses RANKL-mediated osteoclastogenesis by inhibiting c-Fos induction and NF-kappaB pathway and attenuating ROS production.
Authors: Lee S, Lee K, Yi S, Kook S, Lee J
PLoS ONE, 2013;8(12):e80873.
Species: Mouse
Sample Type: whole cells
Application: cell culture
Hepatocyte-specific mutation of both NF-kappaB RelA and STAT3 abrogates the acute phase response in mice.
Authors: Quinton LJ, Blahna MT, Jones MR, Allen E, Ferrari JD, Hilliard KL, Zhang X, Sabharwal V, Algul H, Akira S, Schmid RM, Pelton SI, Spira A, Mizgerd JP
J. Clin. Invest., 2012;122(5):1758-63.
Species: Mouse
Sample Type: In Vivo
Application: In Vivo
Sphingosine-1-phosphate enhances satellite cell activation in dystrophic muscles through a S1PR2/STAT3 signaling pathway.
Authors: Loh KC, Leong WI, Carlson ME
PLoS ONE, 2012;7(5):e37218.
Species: Mouse
Sample Type: Whole Cells
Application: Bioassay
Chemotherapy-triggered cathepsin B release in myeloid-derived suppressor cells activates the Nlrp3 inflammasome and promotes tumor growth.
Authors: Bruchard M, Mignot G, Derangere V, Chalmin F, Chevriaux A, Vegran F, Boireau W, Simon B, Ryffel B, Connat J, Kanellopoulos J, Martin F, Rebe C, Apetoh L, Ghiringhelli F
Nat Med, 2012;19(1):57-64.
Species: Mouse
Sample Type: whole cells
Application: Bioassay
Regulation of innate CD8+ T-cell activation mediated by cytokines.
Proc Natl Acad Sci U S A, 2012;109(25):9971-6.
Species: Mouse
Sample Type: Whole Cells
Application: Bioassay
IL-6 activates STAT5 in T cells.
Authors: Tormo AJ, Letellier MC, Sharma M, Elson G, Crabe S, Gauchat JF
Cytokine, 2012;60(0):575.
Species: Mouse
Sample Type: Whole Cells
Application: Bioassay
Hepatocarcinogenesis in FXR-/- mice mimics human HCC progression that operates through HNF1alpha regulation of FXR expression.
Authors: Liu N, Meng Z, Lou G, Zhou W, Wang X, Zhang Y, Zhang L, Liu X, Yen Y, Lai L, Forman BM, Xu Z, Xu R, Huang W
Mol. Endocrinol., 2012;26(5):775-85.
Species: Mouse
Sample Type: Whole Cells
Application: Bioassay
Interleukin 7 (IL-7) selectively promotes mouse and human IL-17-producing gammadelta cells.
Authors: Michel M, Pang D, Haque S, Potocnik A, Pennington D, Hayday A
Proc Natl Acad Sci U S A, 2012;109(43):17549-54.
Species: Mouse
Sample Type: whole cells
Application: Bioassay
CXCL1 can be regulated by IL-6 and promotes granulocyte adhesion to brain capillaries during bacterial toxin exposure and encephalomyelitis.
Authors: Roy M, Richard JF, Dumas A, Vallieres L
J Neuroinflammation, 2012;9(0):18.
Species: Mouse
Sample Type: Whole Cells
Application: Bioassay
Host-derived MCP-1 and MIP-1alpha regulate protective anti-tumor immunity to localized and metastatic B16 melanoma.
Authors: Nakasone Y, Fujimoto M, Matsushita T, Hamaguchi Y, Huu DL, Yanaba M, Sato S, Takehara K, Hasegawa M
Am. J. Pathol., 2012;180(1):365-74.
Species: Mouse
Sample Type: In Vivo
Application: In Vivo
Robust tumor immunity to melanoma mediated by interleukin-9-producing T cells.
Nat. Med., 2012;1248(0):18.
Species: Mouse
Sample Type: Whole Cells
Application: Bioassay
Contribution of IL-17-producing gamma delta T cells to the efficacy of anticancer chemotherapy.
Authors: Ma Y, Aymeric L, Locher C, Mattarollo SR, Delahaye NF, Pereira P, Boucontet L, Apetoh L, Ghiringhelli F, Casares N, Lasarte JJ, Matsuzaki G, Ikuta K, Ryffel B, Benlagha K, Tesniere A, Ibrahim N, Dechanet-Merville J, Chaput N, Smyth MJ, Kroemer G, Zitvogel L
J. Exp. Med., 2011;208(3):491-503.
Species: Mouse
Sample Type: Whole Cells
Application: Bioassay
Naive and activated T cells display differential responsiveness to TL1A that affects Th17 generation, maintenance, and proliferation.
Authors: Jones GW, Stumhofer JS, Foster T, Twohig JP, Hertzog P, Topley N, Williams AS, Hunter CA, Jenkins BJ, Wang EC, Jones SA
FASEB J., 2011;25(1):409-19.
Species: Mouse
Sample Type: Whole Cells
Application: Bioassay
The encephalitogenicity of T(H)17 cells is dependent on IL-1- and IL-23-induced production of the cytokine GM-CSF.
Authors: El-Behi M, Ciric B, Dai H
Nat. Immunol., 2011;12(6):568-75.
Species: Mouse
Sample Type: Whole Cells
Application: Bioassay
The effect of conditional EFNB1 deletion in the T cell compartment on T cell development and function.
Authors: Jin W, Qi S, Luo H
BMC Immunol., 2011;12(0):68.
Species: Mouse
Sample Type: Whole Cells
Application: Bioassay
Aryl hydrocarbon receptor deficiency in T cells suppresses the development of collagen-induced arthritis.
Authors: Nakahama T, Kimura A, Nguyen NT, Chinen I, Hanieh H, Nohara K, Fujii-Kuriyama Y, Kishimoto T
Proc. Natl. Acad. Sci. U.S.A., 2011;108(34):14222-7.
Species: Mouse
Sample Type: Whole Cells
Application: Bioassay
Leukemia inhibitory factor inhibits T helper 17 cell differentiation and confers treatment effects of neural progenitor cell therapy in autoimmune disease.
Authors: Cao W, Yang Y, Wang Z, Liu A, Fang L, Wu F, Hong J, Shi Y, Leung S, Dong C, Zhang JZ
Immunity, 2011;35(2):273-84.
Species: Mouse
Sample Type: Whole Cells
Application: Bioassay
Smad1 signaling restricts hematopoietic potential after promoting hemangioblast commitment.
Authors: Cook BD, Liu S, Evans T
Blood, 2011;117(24):6489-97.
Species: Mouse
Sample Type: Whole Cells
Application: Bioassay
Regulation of the IL-21 gene by the NF-kappaB transcription factor c-Rel.
Authors: Chen G, Hardy K, Bunting K
J. Immunol., 2010;185(4):2350-9.
Species: Mouse
Sample Type: Whole Cells
Application: Bioassay
TIM-3: a novel regulatory molecule of alloimmune activation.
Authors: Boenisch O, D'Addio F, Watanabe T, Elyaman W, Magee CN, Yeung MY, Padera RF, Rodig SJ, Murayama T, Tanaka K, Yuan X, Ueno T, Jurisch A, Mfarrej B, Akiba H, Yagita H, Najafian N
J. Immunol., 2010;185(10):5806-19.
Species: Mouse
Sample Type: Whole Cells
Application: Bioassay
Cell adhesion molecules regulate fibrotic process via Th1/Th2/Th17 cell balance in a bleomycin-induced scleroderma model.
Authors: Yoshizaki A, Yanaba K, Iwata Y
J. Immunol., 2010;185(4):2502-15.
Species: Mouse
Sample Type: Whole Cells
Application: Bioassay
Interleukin-1 family cytokines as mucosal vaccine adjuvants for induction of protective immunity against influenza virus.
Authors: Kayamuro H, Yoshioka Y, Abe Y, Arita S, Katayama K, Nomura T, Yoshikawa T, Kubota-Koketsu R, Ikuta K, Okamoto S, Mori Y, Kunisawa J, Kiyono H, Itoh N, Nagano K, Kamada H, Tsutsumi Y, Tsunoda S
J. Virol., 2010;84(24):12703-12.
Species: Mouse
Sample Type: In Vivo
Application: In Vivo
Loss of CD4+ T cell IL-6R expression during inflammation underlines a role for IL-6 trans signaling in the local maintenance of Th17 cells.
Authors: Jones GW, McLoughlin RM, Hammond VJ, Parker CR, Williams JD, Malhotra R, Scheller J, Williams AS, Rose-John S, Topley N, Jones SA
J. Immunol., 2010;184(4):2130-9.
Species: Mouse
Sample Type: Whole Cells
Application: Bioassay
Antigen-specific Th9 cells exhibit uniqueness in their kinetics of cytokine production and short retention at the inflammatory site.
Authors: Tan C, Aziz MK, Lovaas JD, Vistica BP, Shi G, Wawrousek EF, Gery I
J. Immunol., 2010;185(11):6795-801.
Species: Human
Sample Type: Whole Cells
Application: Bioassay
IL-6 loss causes ventricular dysfunction, fibrosis, reduced capillary density, and dramatically alters the cell populations of the developing and adult heart.
Authors: Banerjee I, Fuseler JW, Intwala AR, Baudino TA
Am. J. Physiol. Heart Circ. Physiol., 2009;296(5):H1694-704.
Species: Mouse
Sample Type: Whole Cells
Application: Bioassay
Stratification is the key: inflammatory biomarkers accurately direct immunomodulatory therapy in experimental sepsis.
Authors: Osuchowski MF, Connett J, Welch K, Granger J, Remick DG
Crit. Care Med., 2009;37(5):1567-73.
Species: N/A
Sample Type: N/A
Application: ELISA Standard
The role of interleukin-6 in lipopolysaccharide-induced fever by mechanisms independent of prostaglandin E2.
Authors: Nilsberth C, Elander L, Hamzic N, Norell M, Lonn J, Engstrom L, Blomqvist A
Endocrinology, 2009;150(4):1850-60.
Species: Mouse
Sample Type: In Vivo
Application: In Vivo
The induction of antibody production by IL-6 is indirectly mediated by IL-21 produced by CD4+ T cells.
Authors: Dienz O, Eaton SM, Bond JP, Neveu W, Moquin D, Noubade R, Briso EM, Charland C, Leonard WJ, Ciliberto G, Teuscher C, Haynes L, Rincon M
J. Exp. Med., 2009;206(1):69-78.
Species: Mouse
Sample Type: In Vivo
Application: In Vivo
Disruption of interleukin-1 signaling improves the quality of wound healing.
Authors: Thomay AA, Daley JM, Sabo E, Worth PJ, Shelton LJ, Harty MW, Reichner JS, Albina JE
Am. J. Pathol., 2009;174(6):2129-36.
Species: Mouse
Sample Type: In Vivo
Application: In Vivo
Activation of the NLRP3 inflammasome in dendritic cells induces IL-1beta-dependent adaptive immunity against tumors.
Authors: Ghiringhelli F, Apetoh L, Tesniere A, Aymeric L, Ma Y, Ortiz C, Vermaelen K, Panaretakis T, Mignot G, Ullrich E, Perfettini JL, Schlemmer F, Tasdemir E, Uhl M, Genin P, Civas A, Ryffel B, Kanellopoulos J, Tschopp J, Andre F, Lidereau R, McLaughlin NM, Haynes NM, Smyth MJ, Kroemer G, Zitvogel L
Nat. Med., 2009;15(10):1170-8.
Species: Mouse
Sample Type: Whole Cells
Application: Bioassay
ST2 deficient mice display a normal host defense against pulmonary infection with Mycobacterium tuberculosis.
Authors: Wieland CW, van der Windt GJ, Florquin S, McKenzie AN, van der Poll T
Microbes Infect., 2009;11(4):524-30.

Role of Tim-3/galectin-9 inhibitory interaction in viral-induced immunopathology: shifting the balance toward regulators.
Authors: Sehrawat S, Suryawanshi A, Hirashima M, Rouse BT
J. Immunol., 2009;182(5):3191-201.
Species: Mouse
Sample Type: Whole Cells
Application: Bioassay
Thymic regulation of autoimmune disease by accelerated differentiation of Foxp3+ regulatory T cells through IL-7 signaling pathway.
Authors: Chen X, Fang L, Song S, Guo TB, Liu A, Zhang JZ
J. Immunol., 2009;183(10):6135-44.
Species: Mouse
Sample Type: Whole Cells
Application: Bioassay
Externalization of the leaderless cytokine IL-1F6 occurs in response to lipopolysaccharide/ATP activation of transduced bone marrow macrophages.
Authors: Martin U, Scholler J, Gurgel J, Renshaw B, Sims JE, Gabel CA
J. Immunol., 2009;183(6):4021-30.
Species: Mouse
Sample Type: Buffer
Application: WB Ctrl
Interleukin-6 mediates lung injury following ischemic acute kidney injury or bilateral nephrectomy.
Authors: Klein CL, Hoke TS, Fang WF, Altmann CJ, Douglas IS, Faubel S
Kidney Int., 2008;74(7):901-9.
Species: Mouse
Sample Type: In Vivo
Application: In Vivo
GP130-STAT3 regulates epithelial cell migration and is required for repair of the bronchiolar epithelium.
Authors: Kida H, Mucenski ML, Thitoff AR, Le Cras TD, Park KS, Ikegami M, Muller W, Whitsett JA
Am. J. Pathol., 2008;172(6):1542-54.
Species: Mouse
Sample Type: In Vivo
Application: In Vivo
Both Th1 and Th17 are immunopathogenic but differ in other key biological activities.
Authors: Cox CA, Shi G, Yin H, Vistica BP, Wawrousek EF, Chan CC, Gery I
J. Immunol., 2008;180(11):7414-22.
Species: Mouse
Sample Type: Whole Cells
Application: Bioassay
Tumor-specific Th17-polarized cells eradicate large established melanoma.
Authors: Muranski P, Boni A, Antony PA, Cassard L, Irvine KR, Kaiser A, Paulos CM, Palmer DC, Touloukian CE, Ptak K, Gattinoni L, Wrzesinski C, Hinrichs CS, Kerstann KW, Feigenbaum L, Chan CC, Restifo NP
Blood, 2008;112(2):362-73.
Species: Mouse
Sample Type: Whole Cells
Application: Bioassay
Adiponectin blocks multiple signaling cascades associated with leptin-induced cell proliferation in Apc Min/+ colon epithelial cells.
Authors: Fenton JI, Birmingham JM, Hursting SD, Hord NG
Int. J. Cancer, 2008;122(11):2437-45.
Species: Mouse
Sample Type: Whole Cells
Application: Bioassay
CD14 contributes to pulmonary inflammation and mortality during murine tuberculosis.
Authors: Wieland CW, van der Windt GJ, Wiersinga WJ, Florquin S, van der Poll T
Immunology, 2008;125(2):272-9.
Species: N/A
Sample Type: N/A
Application: ELISA Standard
TH17 cells mediate steroid-resistant airway inflammation and airway hyperresponsiveness in mice.
Authors: McKinley L, Alcorn JF, Peterson A, Dupont RB, Kapadia S, Logar A, Henry A, Irvin CG, Piganelli JD, Ray A, Kolls JK
J. Immunol., 2008;181(6):4089-97.
Species: Mouse
Sample Type: Whole Cells
Application: Bioassay
A potential role of thymic stromal lymphopoietin in the recruitment of macrophages to mouse intervertebral disc cells via monocyte chemotactic protein 1 induction: implications for herniated discs.
Authors: Ohba T, Haro H, Ando T, Koyama K, Hatsushika K, Suenaga F, Ohnuma Y, Nakamura Y, Katoh R, Ogawa H, Hamada Y, Nakao A
Arthritis Rheum., 2008;58(11):3510-9.
Species: Mouse
Sample Type: Whole Cells
Application: Bioassay
Sphingosine 1-phosphate regulates the egress of IgA plasmablasts from Peyer's patches for intestinal IgA responses.
Authors: Gohda M, Kunisawa J, Miura F, Kagiyama Y, Kurashima Y, Higuchi M, Ishikawa I, Ogahara I, Kiyono H
J. Immunol., 2008;180(8):5335-43.

The type I IFN induction pathway constrains Th17-mediated autoimmune inflammation in mice.
Authors: Guo B, Chang EY, Cheng G
J. Clin. Invest., 2008;118(5):1680-90.
Species: Mouse
Sample Type: Whole Cells
Application: Bioassay
Engagement of the type I interferon receptor on dendritic cells inhibits T helper 17 cell development: role of intracellular osteopontin.
Authors: Shinohara ML, Kim JH, Garcia VA, Cantor H
Immunity, 2008;29(1):68-78.
Species: Mouse
Sample Type: Whole Cells
Application: Bioassay
High pressure promotes monocyte adhesion to the vascular wall.
Authors: Riou S, Mees B, Esposito B, Merval R, Vilar J, Stengel D, Ninio E, van Haperen R, de Crom R, Tedgui A, Lehoux S
Circ. Res., 2007;100(8):1226-33.
Species: Mouse
Sample Type: Whole Cells
Application: Bioassay
Local stimulation of the adenosine A2B receptors induces an increased release of IL-6 in mouse striatum: an in vivo microdialysis study.
Authors: Vazquez JF, Clement HW, Sommer O, Schulz E, van Calker D
J. Neurochem., 2007;105(3):904-9.
Species: Mouse
Sample Type: In Vivo
Application: In Vivo
Inactivated Sendai virus particles eradicate tumors by inducing immune responses through blocking regulatory T cells.
Authors: Kurooka M, Kaneda Y
Cancer Res., 2007;67(1):227-36.
Species: Mouse
Sample Type: Whole Cells
Application: Bioassay
Maternal immune activation alters fetal brain development through interleukin-6.
Authors: Smith SE, Li J, Garbett K, Mirnics K, Patterson PH
J. Neurosci., 2007;27(40):10695-702.
Species: Mouse
Sample Type: In Vivo
Application: In Vivo
Osteoblasts support B-lymphocyte commitment and differentiation from hematopoietic stem cells.
Authors: Zhu J, Garrett R, Jung Y, Zhang Y, Kim N, Wang J, Joe GJ, Hexner E, Choi Y, Taichman RS, Emerson SG
Blood, 2007;109(9):3706-12.
Species: Mouse
Sample Type: Whole Cells
Application: Bioassay
Effect of chronic IL-6 infusion on acute pressor responses to vasoconstrictors in mice.
Authors: Boesen EI, Pollock DM
Am. J. Physiol. Heart Circ. Physiol., 2007;293(3):H1745-9.
Species: Mouse
Sample Type: In Vivo
Application: In Vivo
Interleukin-6 as a mechanism for the adverse effects of social stress on acute Theiler's virus infection.
Authors: Meagher MW, Johnson RR, Young EE, Vichaya EG, Lunt S, Hardin EA, Connor MA, Welsh CJ
Brain Behav. Immun., 2007;21(8):1083-95.
Species: Mouse
Sample Type: In Vivo
Application: In Vivo
TGF-beta and IL-6 drive the production of IL-17 and IL-10 by T cells and restrain T(H)-17 cell-mediated pathology.
Authors: McGeachy MJ, Bak-Jensen KS, Chen Y, Tato CM, Blumenschein W, McClanahan T, Cua DJ
Nat. Immunol., 2007;8(12):1390-7.
Species: Mouse
Sample Type: Whole Cells
Application: Bioassay
IL-17B and IL-17C are associated with TNF-alpha production and contribute to the exacerbation of inflammatory arthritis.
Authors: Yamaguchi Y, Fujio K, Shoda H, Okamoto A, Tsuno NH, Takahashi K, Yamamoto K
J. Immunol., 2007;179(10):7128-36.
Species: Mouse
Sample Type: Whole Cells
Application: Bioassay
Induction of a distinct CD8 Tnc17 subset by transforming growth factor-beta and interleukin-6.
Authors: Liu SJ, Tsai JP, Shen CR, Sher YP, Hsieh CL, Yeh YC, Chou AH, Chang SR, Hsiao KN, Yu FW, Chen HW
J. Leukoc. Biol., 2007;82(2):354-60.
Species: Mouse
Sample Type: Whole Cells
Application: Bioassay
Adenoviral-mediated overexpression of SOCS3 enhances IgG immune complex-induced acute lung injury.
Authors: Gao H, Hoesel LM, Guo RF, Rancilio NJ, Sarma JV, Ward PA
J. Immunol., 2006;177(1):612-20.
Species: Mouse
Sample Type: In Vivo
Application: In Vivo
The pulmonary and hepatic immune microenvironment and its contribution to the early systemic inflammation following blunt chest trauma.
Authors: Perl M, Gebhard F, Braumuller S, Tauchmann B, Bruckner UB, Kinzl L, Knoferl MW
Crit. Care Med., 2006;34(4):1152-9.
Species: Mouse
Sample Type: In Vivo
Application: In Vivo
Reciprocal developmental pathways for the generation of pathogenic effector TH17 and regulatory T cells.
Authors: Bettelli E, Carrier Y, Gao W, Korn T, Strom TB, Oukka M, Weiner HL, Kuchroo VK
Nature, 2006;441(7090):235-8.
Species: Mouse
Sample Type: Whole Cells
Application: Bioassay
Somatic activation of a conditional KrasG12D allele causes ineffective erythropoiesis in vivo.
Authors: Braun BS, Archard JA, Van Ziffle JA, Tuveson DA, Jacks TE, Shannon K
Blood, 2006;108(6):2041-4.
Species: Mouse
Sample Type: Whole Cells
Application: Bioassay
Glechoma hederacea inhibits inflammatory mediator release in IFN-gamma and LPS-stimulated mouse peritoneal macrophages.
Authors: An HJ, Jeong HJ, Um JY, Kim HM, Hong SH
J Ethnopharmacol, 2006;106(3):418-24.
Species: N/A
Sample Type: N/A
Application: ELISA Standard
Circulating cytokine/inhibitor profiles reshape the understanding of the SIRS/CARS continuum in sepsis and predict mortality.
Authors: Osuchowski MF, Welch K, Siddiqui J, Remick DG
J. Immunol., 2006;177(3):1967-74.
Species: N/A
Sample Type: N/A
Application: ELISA Standard
Hemojuvelin is essential for dietary iron sensing, and its mutation leads to severe iron overload.
Authors: Niederkofler V, Salie R, Arber S
J. Clin. Invest., 2005;115(8):2180-6.
Species: Mouse
Sample Type: In Vivo
Application: In Vivo
Sequential ELISA to profile multiple cytokines from small volumes.
Authors: Osuchowski MF, Siddiqui J, Copeland S, Remick DG
J. Immunol. Methods, 2005;302(1):172-81.
Species: N/A
Sample Type: N/A
Application: ELISA Standard
Role of interleukin-6 in cardiomyocyte/cardiac fibroblast interactions during myocyte hypertrophy and fibroblast proliferation.
Authors: Fredj S, Bescond J, Louault C, Delwail A, Potreau D
J. Cell. Physiol., 2005;204(2):428-36.
Species: N/A
Sample Type: N/A
Application: ELISA Standard
Pivotal role of endogenous tachykinins and the NK1 receptor in mediating leukocyte accumulation, in the absence of oedema formation, in response to TNFalpha in the cutaneous microvasculature.
Authors: Costa SK, Yshii LM, Poston RN, Muscara MN, Brain SD
J. Neuroimmunol., 2005;171(1):99-109.
Species: Mouse
Sample Type: In Vivo
Application: In Vivo
SLAM family markers are conserved among hematopoietic stem cells from old and reconstituted mice and markedly increase their purity.
Authors: Yilmaz OH, Kiel MJ, Morrison SJ
Blood, 2005;107(3):924-30.
Species: Mouse
Sample Type: Whole Cells
Application: Bioassay
Selective macrophage suppression during sepsis.
Authors: Ellaban E, Bolgos G, Remick D
Cell. Immunol., 2004;231(1):103-11.
Species: N/A
Sample Type: N/A
Application: ELISA Standard
CXCR2-/- mice show enhanced susceptibility to herpetic stromal keratitis: a role for IL-6-induced neovascularization.
Authors: Banerjee K, Biswas PS, Kim B, Lee S, Rouse BT
J. Immunol., 2004;172(2):1237-45.
Species: Mouse
Sample Type: In Vivo
Application: In Vivo
Cardiotrophin-1 in choroid plexus and the cerebrospinal fluid circulatory system.
Authors: Gard AL, Gavin E, Solodushko V, Pennica D
Neuroscience, 2004;127(1):43-52.
Species: N/A
Sample Type: N/A
Application: WB Ctrl
The IL-6 family cytokines, interleukin-6, interleukin-11, oncostatin M, and leukemia inhibitory factor, enhance mast cell growth through fibroblast-dependent pathway in mice.
Authors: Gyotoku E, Morita E, Kameyoshi Y, Hiragun T, Yamamoto S, Hide M
Arch. Dermatol. Res., 2001;293(10):508-14.
Species: Mouse
Sample Type: Whole Cells
Application: Bioassay
Interleukin-6 and the granulocyte colony-stimulating factor receptor are major independent regulators of granulopoiesis in vivo but are not required for lineage commitment or terminal differentiation.
Authors: Liu F, Poursine-Laurent J, Wu HY, Link DC
Blood, 1997;90(7):2583-90.
Species: Mouse
Sample Type: In Vivo
Application: In Vivo

rmIL-6 (200 ug)