R&D Systems_BMP-2 Quantikine ELISA Kit _优宁维(univ)在线
BMP-2 Quantikine ELISA Kit
商品编码: DBP200 品牌: R&D Systems 反应种属:
Natural and mammalian-expressed recombinant human BMP-2.  This assay does not recognize E. coli-expressed BMP-2.
Natural and mammalian-expressed recombinant human BMP-2.  This assay does not recognize E. coli-expressed BMP-2.
货号 规格 价格 库存 数量 操作
DBP200 1Kit ¥7811.00
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    产品介绍相关商品
    产品信息
    产品形式
    96-well strip plate
    商品描述
    The Quantikine Human BMP-2 Immunoassay is a 4.5 hour solid-phase ELISA designed to measure human BMP-2 in bone tissue extracts and cell culture supernates. It contains CHO cell-expressed recombinant human BMP-2 and has been shown to accurately quantitate the recombinant factor. Results obtained using natural mouse BMP-2 showed linear curves that were parallel to the standard curves obtained using the Quantikine kit standards. These results indicate that this kit can be used to determine relative mass values for naturally occurring human BMP-2.
    应用
    样本类型以及上样量
    Cell Culture Supernates (50 uL), Bone Extracts (50 uL)
    反应种属
    Natural and mammalian-expressed recombinant human BMP-2.  This assay does not recognize E. coli-expressed BMP-2.
    背景
    背景

    BMPs are secreted signaling molecules that comprise a subfamily of the TGF-beta superfamily and were originally identified as regulators of cartilage and bone formation. There are at least 20 structurally and functionally related BMPs, most of which play roles in embryogenesis and morphogenesis of various tissues and organs. Biologically active BMPs are usually homodimers containing a characteristic cysteine knot structure. Heterodimers, BMP-2/BMP-7 and BMP-4/BMP-7 have also been suggested to exist and function in vivo. They are more potent inducers of bone formation than their respective homodimers. In addition, heterodimers, but not homodimers, are ventral mesoderm inducers. Heterodimer activity may be mediated by a different or additional receptor subtype.

    Decapentaplegic (Dpp) is one of at least five TGF-beta superfamily ligands identified in the Drosophila genome. Dpp, a functional ortholog of mammalian BMP-2 and BMP-4, is a morphogen and plays an essential role in Drosophila development. Dpp regulates embryonic dorsal-ventral polarity and is required for gut morphogenesis and outgrowth and patterning of imaginal disks.

    别名
    BMP-2; BMP-2A; BMP2ABone morphogenetic protein 2A; bone morphogenetic protein 2;
    文献
    文献
    R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.

    Targeted next-generation sequencing reveals multiple deleterious variants in OPLL-associated genes
    Authors: Xin Chen
    Sci Rep, 2016;6(0):26962.
    Species: Human
    Sample Type: Plasma

    Facilitated receptor-recognition and enhanced bioactivity of bone morphogenetic protein-2 on magnesium-substituted hydroxyapatite surface
    Authors: B Huang, Y Yuan, T Li, S Ding, W Zhang, Y Gu, C Liu
    Sci Rep, 2016;6(0):24323.
    Species: Mouse
    Sample Type: Cell Culture Supernates

    Modified mRNA for BMP 2 in combination with biomaterials serves as a transcript activated matrix for effectively inducing osteogenic pathways in stem cells
    Stem Cells Dev, 2016;0(0):.
    Species: Rat
    Sample Type: Cell Culture Supernates

    Identifying an ovarian cancer cell hierarchy regulated by bone morphogenetic protein 2.
    Authors: Choi Y, Ingram P, Yang K, Coffman L, Iyengar M, Bai S, Thomas D, Yoon E, Buckanovich R
    Proc Natl Acad Sci U S A, 2015;112(50):E6882-8.
    Species: Human
    Sample Type: Cell Culture Supernates

    Increased plasma BMP-2 levels are associated with atherosclerosis burden and coronary calcification in type 2 diabetic patients.
    Authors: Zhang M, Sara J, Wang F, Liu L, Su L, Zhe J, Wu X, Liu J
    Cardiovasc Diabetol, 2015;14(0):64.
    Species: Human
    Sample Type: Plasma

    Dental follicle stem cells in bone regeneration on titanium implants.
    Authors: Lucaciu O, Soritau O, Gheban D, Ciuca D, Virtic O, Vulpoi A, Dirzu N, Campian R, Baciut G, Popa C, Simon S, Berce P, Baciut M, Crisan B
    BMC Biotechnol, 2015;15(1):114.
    Species: Human
    Sample Type: Cell Culture Supernates

    Designing nanotopographical density of extracellular matrix for controlled morphology and function of human mesenchymal stem cells.
    Authors: Kim J, Kim H, Lim K, Kim Y, Seonwoo H, Park S, Lim H, Kim D, Suh K, Choung P, Choung Y, Chung J
    Sci Rep, 2013;3(0):3552.
    Species: Human
    Sample Type: Cell Culture Supernates

    Bone morphogenetic protein-2/-4 upregulation promoted by endothelial cells in coculture enhances mouse embryoid body differentiation.
    Authors: Talavera-Adame, Dodanim, Gupta, Ankur, Kurtovic, Silvia, Chaiboonma, Kira L, Arumugaswami, Vaithili, Dafoe, Donald C
    Stem Cells Dev, 2013;22(24):3252-60.
    Species: Human
    Sample Type: cell culture supernate

    The serum bone morphogenetic protein-2 level in non-small-cell lung cancer patients.
    Authors: Choi YJ, Kim ST, Park KH, Oh SC, Seo JH, Shin SW, Kim JS, Kim YH
    Med. Oncol., 2012;29(0):582-8.
    Species: Human
    Sample Type: Serum

    Association of bone morphogenetic proteins with spinal fusion in ankylosing spondylitis.
    Authors: Chen HA, Chen CH, Lin YJ, Chen PC, Chen WS, Lu CL, Chou CT
    J. Rheumatol., 2010;37(10):2126-32.
    Species: Human
    Sample Type: Serum

    Bone morphogenetic protein-2 may represent the molecular link between oxidative stress and vascular stiffness in chronic kidney disease.
    Authors: Dalfino G, Simone S, Porreca S, Cosola C, Balestra C, Manno C, Schena FP, Grandaliano G, Pertosa G
    Atherosclerosis, 2010;211(2):418-23.
    Species: Human
    Sample Type: Serum

    Bone marrow cells are a rich source of growth factors and cytokines: implications for cell therapy trials after myocardial infarction.
    Authors: Korf-Klingebiel M, Kempf T, Sauer T, Brinkmann E, Fischer P, Meyer GP, Ganser A, Drexler H, Wollert KC
    Eur. Heart J., 2008;29(23):2851-8.
    Species: Human
    Sample Type: Cell Culture Supernates

    Isolation and characterization of CD146+ multipotent mesenchymal stromal cells.
    Authors: Sorrentino A, Ferracin M, Castelli G, Biffoni M, Tomaselli G, Baiocchi M, Fatica A, Negrini M, Peschle C, Valtieri M
    Exp. Hematol., 2008;36(8):1035-46.
    Species: Human
    Sample Type: Cell Culture Supernates

    Periodontal regeneration using ex vivo autologous stem cells engineered to express the BMP-2 gene: an alternative to alveolaplasty.
    Authors: Chen YL, Chen PK, Jeng LB, Huang CS, Yang LC, Chung HY, Chang SC
    Gene Ther., 2008;15(22):1469-77.
    Species: Rabbit
    Sample Type: Cell Culture Supernates

    Activin-like kinase receptor 1 (ALK1) in atherosclerotic lesions and vascular mesenchymal cells.
    Authors: Yao Y, Zebboudj AF, Torres A, Shao E, Bostrom K
    Cardiovasc. Res., 2007;74(2):279-89.
    Species: Human
    Sample Type: Cell Culture Supernates

    Mesenchymal stem cells support migration, extracellular matrix invasion, proliferation, and survival of endothelial cells in vitro.
    Authors: Potapova IA, Gaudette GR, Brink PR, Robinson RB, Rosen MR, Cohen IS, Doronin SV
    Stem Cells, 2007;25(7):1761-8.
    Species: Human
    Sample Type: Cell Culture Supernates

    Quantitative assessment of growth factors in reaming aspirate, iliac crest, and platelet preparation.
    Authors: Herrmann S, Green J, Weber T, Scharfenberger A
    Bone, 2006;39(5):1156-63.
    Species: Human
    Sample Type: Tissue Homogenates

    Direct adenoviral transfer of bone morphogenetic protein-2 cDNA enhances fracture healing in osteoporotic sheep.
    Authors: Egermann M, Baltzer AW, Adamaszek S, Evans C, Robbins P, Schneider E, Lill CA
    Hum. Gene Ther., 2006;17(5):507-17.
    Species: Ovine
    Sample Type: Cell Culture Supernates

    Targeted delivery system for juxtacrine signaling growth factor based on rhBMP-2-mediated carrier-protein conjugation.
    Authors: Liu HW, Chen CH, Tsai CL, Hsiue GH
    Bone, 2006;39(4):825-36.
    Species: Human
    Sample Type: recombinant BMP-2

    Combinatorial gene therapy for bone regeneration: cooperative interactions between adenovirus vectors expressing bone morphogenetic proteins 2, 4, and 7.
    Authors: Zhao M, Zhao Z, Koh JT, Jin T, Franceschi RT
    J. Cell. Biochem., 2005;95(1):1-16.
    Species: Mouse
    Sample Type: Cell Culture Supernates

    Measurement of bone morphogenetic proteins and other growth factors in demineralized bone matrix.
    Authors: Blum B, Moseley J, Miller L, Richelsoph K, Haggard W
    Orthopedics, 2004;27(1):161-5.
    Species: Rat
    Sample Type: Tissue Homogenates

    Shock wave application enhances pertussis toxin protein-sensitive bone formation of segmental femoral defect in rats.
    Authors: Chen YJ, Kuo YR, Yang KD, Wang CJ, Huang HC, Wang FS
    J. Bone Miner. Res., 2003;18(12):2169-79.
    Species: Rat
    Sample Type: Serum

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