Novus_Mouse Monoclonal HIF-1 alpha Antibody (H1alpha67) [Alexa Fluor® 405]_优宁维(univ)在线
Mouse Monoclonal HIF-1 alpha Antibody (H1alpha67) [Alexa Fluor® 405]
商品编码: NB100-105AF405 品牌: Novus 同种亚型:
IgG2b
IgG2b
反应种属:
Hu, Mu, Rt, Po, Bv, Ft, Mk, Pm, Rb, Sh, Xp, YeSpecies Glossary
Hu, Mu, Rt, Po, Bv, Ft, Mk, Pm, Rb, Sh, Xp, YeSpecies Glossary
应用:
WB, ChIP, ELISA, Flow, GS, ICC/IF, IHC, IHC-Fr, IHC-P, IP, LA, TCS
WB, ChIP, ELISA, Flow, GS, ICC/IF, IHC, IHC-Fr, IHC-P, IP, LA, TCS
来源宿主: Mouse
货号 规格 价格 库存 数量 操作
NB100-105AF405 0.1ml ¥6250.00
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    产品介绍相关商品
    产品信息
    克隆类别
    Monoclonal
    纯度
    Protein G purified
    宿主
    Mouse
    浓度
    1.0 mg/ml
    同种型
    IgG2b
    应用
    实验应用
    WB, ChIP, ELISA, Flow, GS, ICC/IF, IHC, IHC-Fr, IHC-P, IP, LA, TCS
    反应种属
    Hu, Mu, Rt, Po, Bv, Ft, Mk, Pm, Rb, Sh, Xp, YeSpecies Glossary
    背景
    背景
    HIF1 (hypoxia-inducible factor 1), a heterodimeric transcription factor complex central to cellular response to hypoxia, consists of two subunits (HIF-1 alpha and HIF-1 beta) which are basic helix-loop-helix proteins of the PAS (Per, ARNT, Sim) family. Expression of HIF-1 alpha protein is regulated by cellular oxygen level alterations as well as in oxygen-independent manner via different cytokines (through the PI3K-AKT-mTOR pathway), growth factors, oncogenic activation, or loss of tumor suppressor function etc. In normoxic cells, HIF-1 alpha is proline hydroxylated leading to a conformational change that promotes its binding to the VHL (von Hippel Lindau) protein E3 ligase complex; ubiquitination and followed by rapid proteasomal degradation. Hypoxia as well as chemical hydroxylase inhibitors (desferrioxamine, cobalt etc.) inhibit HIF-1 alpha degradation and lead to its accumulation in the cells, whereas, contrastingly, HIF-1 beta/ARNT (AhR nuclear translocator) remains stable under both conditions. Besides their critical role in hypoxic response, HIF1s regulates the transcription of genes responsible for angiogenesis, erythropoiesis/iron-metabolism, glucose metabolism, cell proliferation/survival, adipogenesis, carotid body formation, B lymphocyte development and immune reactions.
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