Prostate Specific Membrane Antigen (D7I8E) XP ® Rabbit mAb (BSA and Azide Free)

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Prostate Specific Membrane Antigen (D7I8E) XP ® Rabbit mAb (BSA and Azide Free)

品牌： CST

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产品介绍

产品信息

荧光素标记

Unconjugated

来源纯化

Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues in the extracellular domain of human prostate specific membrane antigen protein.

宿主

Rabbit

商品描述

Product Usage Information

This product is the carrier free version of product #12815. All data were generated using the same antibody clone in the standard formulation which contains BSA and glycerol.

This formulation is ideal for use with technologies requiring specialized or custom antibody labeling, including fluorophores, metals, lanthanides, and oligonucleotides. It is not recommended for ChIP, ChIP-seq, CUT&RUN or CUT&Tag assays. If you require a carrier free formulation for chromatin profiling, please contact us. Optimal dilutions/concentrations should be determined by the end user.

BSA and Azide Free antibodies are quality control tested by size exclusion chromatography (SEC) to determine antibody integrity.

同种型

Rabbit IgG

分子量

100

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应用

目标/特异性

Specificity/Sensitivity

Prostate Specific Membrane Antigen (D7I8E) XP Rabbit mAb (BSA and Azide Free) recognizes endogenous levels of total prostate specific membrane antigen. An SDS resistant dimer at approximately 200 kDa can be detected depending on sample preparation conditions.

Species Reactivity:

Human, Mouse, Rat

敏感性

Endogenous

背景

Prostate specific membrane antigen (PSMA, also known as FOLH1), a type II transmembrane protein of the M28 family, has both folate hydrolase and N-acetylated-alpha-linked acidic dipeptidase activity. PSMA was originally identified in the LNCaP cell line, which was derived from a prostate adenocarcinoma lymph node metastasis (1,2). PSMA is an established prostate cancer marker (3); however, it is expressed in other tissues, including kidney, liver, and urinary bladder (4), and it is associated with tumor neovasculature (5) as well. Research studies suggest that PSMA is both a potential diagnostic readout and therapeutic target (6-8). 1.Horoszewicz, J.S. et al. (1987) Anticancer Res 7, 927-35. 2.Israeli, R.S. et al. (1993) Cancer Res 53, 227-30. 3.Ben Jemaa, A. et al. (2010) J Exp Clin Cancer Res 29, 171. 4.Kinoshita, Y. et al. (2006) World J Surg 30, 628-36. 5.Chang, S.S. et al. (1999) Mol Urol 3, 313-320. 6.Mease, R.C. et al. (2013) Curr Top Med Chem 13, 951-62. 7.Frigerio, B. et al. (2013) Eur J Cancer 49, 2223-32. 8.Denmeade, S.R. et al. (2012) Sci Transl Med 4, 140ra86.

翻译后修饰

unmodified

制备和贮存

保存方式

Store at -20°C. This product will freeze at -20°C so it is recommended to aliquot into single-use vials to avoid multiple freeze/thaw cycles. A slight precipitate may be present and can be dissolved by gently vortexing. This will not interfere with antibody performance.

数据库链接

Entrez-Gene ID

2346

UniProt ID

Q04609

参考图片

Immunohistochemical analysis of paraffin-embedded human prostate adenocarcinoma using Prostate Specific Membrane Antigen (D7I8E) XP® Rabbit mAb in the presence of control peptide (left) or antigen-specific peptide (right). Data were generated using the standard formulation of this product.

Western blot analysis of extracts from various cell lines using Prostate Specific Membrane Antigen (D7I8E) XP® Rabbit mAb (upper) or β-Actin (D6A8) Rabbit mAb #8457 (lower). Data were generated using the standard formulation of this product.

Immunohistochemical analysis of paraffin-embedded human prostate adenocarcinoma using Prostate Specific Membrane Antigen (D7I8E) XP® Rabbit mAb. Data were generated using the standard formulation of this product.

Immunohistochemical analysis of paraffin-embedded human ovarian serous adenocarcinoma using Prostate Specific Membrane Antigen (D7I8E) XP® Rabbit mAb. Note positive staining of blood vessels. Data were generated using the standard formulation of this product.

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货号：

92728SF

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询价

100ug

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