PSD-95 (N-Term) Rabbit Monoclonal Antibody (Clone RM288)

Rabbit

Peptide from the N-terminal region of human PSD-95

Postsynaptic density protein-95 (PSD-95) is a scaffold protein and member of the membrane-associated guanylate kinase (MAGUK) family encoded by the DLG4 gene in humans.1,2 It is composed of three N-terminal PDZ domains that facilitate protein-protein interactions and are subject to palmitoylation, which regulates its membrane localization, a Src homology domain that interacts with the tyrosine kinases Src, Lyn, and Yes, and a C-terminal catalytically inactive guanylate kinase domain.1 PSD-95 is expressed in excitatory synapses and localizes to the postsynaptic density, a network of proteins that facilitates the stabilization and trafficking of receptors and ion channels to the postsynaptic membrane.1,3 PSD-95 interacts with the transmembrane AMPA receptor-associated protein stargazin, as well as the NR2 subunit of the NMDA receptor, regulating glutamatergic signaling, synaptic plasticity, and neurodevelopment.1,4 DLG4 mutations have been found in patients with schizophrenia or autism.1 Cayman's PSD-95 (N-Term) Rabbit Monoclonal Antibody (Clone RM288) can be used for immunohistochemistry (IHC) and Western blot (WB) applications.WARNING This product is not for human or veterinary use.

For immunochemical detection of PSD-95

IgG

RM288

Antibodies/Primary Antibodies/Monoclonal Antibodies

Immunohistochemistry,Western Blot

(+) Human (+) Mouse

(+) PSD-95

Synonyms:Postsynaptic Density Protein-95

≥ 1 year