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产品介绍
产品介绍
产品信息
抗原名称
Neuroendocrine peptide which is a critical regulator of cellular and organ growth, development, migration, differentiation and survival and of epithelial calcium ion transport. Regulates endochondral bone development and epithelial-mesenchymal interactions during the formation of the mammary glands and teeth. Required for skeletal homeostasis. Promotes mammary mesenchyme differentiation and bud outgrowth by modulating mesenchymal cell responsiveness to BMPs. Up-regulates BMPR1A expression in the mammary mesenchyme and this increases the sensitivity of these cells to BMPs and allows them to respond to BMP4 in a paracrine and/or autocrine fashion. BMP4 signaling in the mesenchyme, in turn, triggers epithelial outgrowth and augments MSX2 expression, which causes the mammary mesenchyme to inhibit hair follicle formation within the nipple sheath (By similarity). Promotes colon cancer cell migration and invasion in an integrin alpha-6/beta-1-dependent manner through activation of Rac1.. Osteostatin is a potent inhibitor of osteoclastic bone resorption.
宿主
Rabbit
免疫原
Recombinant fragment corresponding to Human PTHLH aa 1 to the C-terminus.Database link: P12272 Run BLAST with Run BLAST with
简单描述
兔多克隆抗体to PTHLH
商品描述
Rabbit Polyclonal PTHLH antibody. Suitable for IHC-P, ICC/IF and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human PTHLH aa 1 to C-terminus.
同种型
IgG
克隆类别
多克隆
纯度
Immunogen affinity purified
浓度
0.1 mg/mL 本产品的浓度可能与批次相关
形式
Liquid
研究领域
细胞生物学
应用
实验应用
ICC/IF, IHC-P
反应种属
Human
背景
别名
PTHRP, PTHLH, Parathyroid hormone-related protein, PTH-rP, PTHrP, Parathyroid hormone-like protein, PLP
研究领域
Signal Transduction Growth Factors/Hormones Hormones Cell Biology Cell Cycle Cell differentiation Stem Cells Mesenchymal Stem Cells Surface Molecules
制备和贮存
存储溶液
pH: 7.20Preservative: 0.02% Sodium azideConstituents: 40% Glycerol (glycerin, glycerine), PBS
保存方式
Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle.
数据库链接
UniProt ID
P12272&&P12272&&P58073&&P52211&&P12272&&Q9GLC7&&P13085
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