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产品介绍
产品介绍
产品信息
抗原名称
Smoothened
商品描述
Purmorphamine, which directly binds and activates Smoothened, blocks BODIPY-cyclopamine binding to Smo with IC50 of ~ 1.5 μM and also is an inducer of osteoblast differentiation with EC50 of 1 μM.
分子量
520.62
纯度
＞98%
可溶性
DMSO : 52.1 mg/mL (100 mM)
外观
white to beige powder
In vitro(体外研究)
Purmorphamine activates the Hedgehog pathway by directly binds and activates Smoothened with IC50 of ~ 1.5 μM in compete with cyclopamine, a Smo antagonist. Purmorphamine is a potent inducer of osteogenesis in multipotent C3H10T1/2 cells. The EC50 (based on ALP expression) for Purmorphamine is 1 μM in C3H10T1/2 cells. Purmorphamine (1 μM) and BMP-4 (100 ng/mL) together increase ALP activity more than 90-fold in 3T3-L1 cells. In contrast to BMP-4, Purmorphamine induces osteogenesis by activating Hedgehog signaling in multipotent mesenchymal progenitor cells.
In vivo(体内研究)
Purmorphamine up-regulates ALP expression in human mesenchymal stem cell-based constructs on rats.
背景
别名
嘌呤胺；Shh Signaling Antagonist VI
分子式
C31H32N6O2
CAS号
483367-10-8
制备和贮存
保存方式
Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution.
参考图片
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