PVR/CD155 (D8A5G) Rabbit mAb

Poliovirus receptor (PVR), also known as CD155 and nectin-like 5 (Necl-5), is an immunoglobulin-like, transmembrane glycoprotein originally described as a mediator of poliovirus attachment to cells and later identified as important in adherens junction formation. PVR binds nectin-3 and interacts with integrin αvβ3 and PDGFR to regulate integrin clustering and focal contact formation at the leading edge of migrating cells (1,2). Research studies demonstrate that PVR and nectin-3 regulate contact inhibition during cell motility and proliferation in transformed 3T3 cells (3). Additional research indicates that PVR expression may play a role in the invasiveness of lung adenocarcinoma (4,5). In the immune system, CD155 plays a role in natural killer (NK) cell-mediated cytotoxicity (6). 1.Takai, Y. et al. (2008) Nat Rev Mol Cell Biol 9, 603-15. 2.Sakisaka, T. et al. (2007) Curr Opin Cell Biol 19, 593-602. 3.Minami, Y. et al. (2007) Biochem Biophys Res Commun 352, 856-60. 4.Tane, S. et al. (2013) Exp Mol Pathol 94, 330-5. 5.Nakai, R. et al. (2010) Cancer Sci 101, 1326-30. 6.Stanietsky, N. and Mandelboim, O. (2010) FEBS Lett 584, 4895-900.