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PFI-2 hydrochloride
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产品介绍
产品介绍
产品信息
抗原名称
SETD7
商品描述
PFI-2 is a novel potent and selective SETD7 histone lysine methyltransferase inhibitor with IC50 ~2 nM. It has > 100-fold selectivity over other methyltransferases and other non-epigenetic targets.
分子量
535.98
纯度
>98%
可溶性
DMSO : 50 mg/mL
外观
white to beige powder
In vitro(体外研究)
(R)-PFI-2 shows 500-fold more inhibitory activity against human SETD7 than its enantiomer, (S)-PFI-2. In a cellular environment, through direct interactions with SETD7, affects Yes-Associated protein localization and phenocopies Setd7 genetic deletion on Hippo pathway signaling.
背景
分子式
C23H26ClF4N3O3S
CAS号
1627607-87-7
制备和贮存
保存方式
Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution.
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