Rabbit Polyclonal Anti-MOTS-c antibody

MOTS-c

兔

Full-length peptide corresponding to amino acids 1-16 on MOTS-c.

Description: Affinity Purified Mitochondrial-Derived Peptide MOTS-c Antibody Overview: Mitochondria are functioning organelles that play a secondary role in signaling within the cell. While the details of mitochondrial signaling are not fully understood, the identification of an open reading frame in the mitochondrial DNA coding for humanin suggests that there are more signaling peptides coded by portions of the mtDNA. A short open reading frame within the 12S subunit of the mitochondrial ribosomal RNA codes for a 16 amino acid peptide called mitochondrial open reading frame of 12S rRNA-c, or MOTS-c. MOTS-c plays a role in insulin sensitivity and metabolic homeostasis (1). MOTS-c targets skeletal muscle tissue, and the mechanism of its action involves inhibition of the folate cycle. MOTS-c promotes the formation of an endogenous AMP analog called 5-aminoimidazole-4-carboxamide ribonucleotide (AICAR). AICAR is an activator of AMPK, suggesting that MOTS-c could be used in an insulin-regulation capacity in order to treat type 2 diabetes (2). MOTS-c selective antibodies were generated against a peptide taken from the human protein. The MOTS-c-selective antibodies are affinity purified on an immobilized antigen based affinity matrix, the isolated antibodies were then stabilized in antibody stabilization buffer for long-term storage. The MOTS-c-selective antibodies are fully characterized for applications in western blotting and ELISA at the recommended dilutions. The lab provides MOTS-c Western blot positive control samples in “ready-to-use” SDS-PAGE sample buffer. Antigenic blocking peptide for MOTS-c antibody is also available, please inquire before ordering. The lab can conjugate this antibody to fluorophores and other secondary enzymes as an additional service.

Affinity Purified Immunoglobulins

Polyclonal

线粒体开放阅读框蛋白抗体;磷酸盐缓冲液

ELISA (EIA), Immunoprecipitation (IP), Western Blot (WB), Dot Blot (DB)

Mitochondrial Derived Peptide MOTS-c; MOTS; MOTS c