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Rabbit Polyclonal Smad2 [p Ser465, p Ser467] Antibody
![Rabbit Polyclonal Smad2 [p Ser465, p Ser467] Antibody](https://shopimg.univ-bio.com/pc/images/20240515/4a1474065be14250b980be5c2b2e4a65.png)
Rabbit Polyclonal Smad2 [p Ser465, p Ser467] Antibody
品牌： Novus
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对比
咨询分子量：
52 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.
纯度：
Antigen Affinity-purified
产品介绍
产品介绍
产品信息
荧光素标记
Unconjugated
宿主
Rabbit
免疫原
Carrier-protein conjugated synthetic peptide surrounding phospho Ser465/Ser467 of human Smad2. The exact sequence is proprietary.
简单描述
Centrifuge briefly prior to opening.
商品描述
Centrifuge briefly prior to opening.
同种型
IgG
分子量
52 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.
克隆类别
Polyclonal
纯度
Antigen Affinity-purified
防腐剂
0.025% Proclin 300
基因
SMAD2
应用
实验应用
WB, Flow, ICC/IF
反应种属
Hu, Mu, Po, Xp
稀释度
Flow Cytometry Immunocytochemistry/ Immunofluorescence 1:100-1:1500Western Blot 1:500-1:3000
背景
别名
This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.
背景
Smad 2 is a member of the Mothers Against Dpp (MAD)-related family of proteins. So far, nine Smads have been identified and can be divided in 3 subgroups based on their structure and functions; pathway-restricted, common mediator and inhibitory Smad. Smad 2 and 3 serve as pathway-restricted Smads for the TGF-beta/activin signaling pathways (1-2). Smad 2 is phosphorylated by the TGF-beta type 1 receptor kinase on Ser 465 and Ser 467. Phosphorylation of both serines is essential for Smad 2-Smad4 heteromeric complex and dissociation of Smad 2 from the TGF-beta type 1 receptor (3). Once phosphorylated Smad2 translocate to the nucleus where it associates with DNA-binding proteins and forming a transcriptional complex (4). Unlike Smad 3 and 4, Smad 2 does not directly bind DNA (5).
制备和贮存
保存方式
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
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