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产品介绍
产品介绍
产品信息
抗原名称
TNF-α
商品描述
(Rac)-Benpyrine is a racemate of Benpyrine. (Rac)-Benpyrine is a potent and orally active TNF-α inhibitor and has the potential for TNF-α mediated inflammatory and autoimmune disease research.
分子量
308.34
纯度
98%
可溶性
DMSO : 12.5 mg/mL (40.54 mM; Need ultrasonic)
In vitro(体外研究)
(Rac)-Benpyrine (Compound 001; 5-10 μM; 24 hours) treatment inhibits the expression level of TNF-α downstream pathway protein NF-κB in the nucleus in RAW264.7 macrophages.
In vivo(体内研究)
(Rac)-Benpyrine (Compound 001; 25-50 mg/kg; oral gavage; daily; for 3 weeks; Kunming mice) treatment obviously reduces the inflammatory cytokines IFN-γ, IL-1β and IL-6 in the blood serum, and the anti-inflammatory factor IL-10 is obviously increased, the foot swelling degree of the arthritis part is also obviously slowed down, and the weight index increase caused by the arthritis also has no obvious reduction.
背景
别名
Benpyrine racemate
分子式
C16H16N6O
CAS号
1333714-43-4
制备和贮存
保存方式
Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution.
参考图片
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